{"id":"bdb4fffc-98f6-5664-bbe7-672021071d7e","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-mouse-nrf2-required","predicate":"is_required_for_tested_response","statement":"Nrf2 knockout mice did not show the ischemic protection observed with systemic SAC in wild-type mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4b777d9f-d1ac-5be7-adcc-262858a410ec","mechanism_event_label":"Removing the pathway changed the response to SAC.","subject":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"object":{"id":"cdb63209-e381-5dcd-88cd-d846d928c711","slug":"mouse-sac-ischemic-protection","display_name":"SAC-associated protection in mouse cerebral ischemia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4b777d9f-d1ac-5be7-adcc-262858a410ec","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-mouse-nrf2-required-event","event_type":"observed_relationship","label":"Removing the pathway changed the response to SAC.","description":"Nrf2 knockout mice did not show the ischemic protection observed with systemic SAC in wild-type mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cdb63209-e381-5dcd-88cd-d846d928c711","slug":"mouse-sac-ischemic-protection","display_name":"SAC-associated protection in mouse cerebral ischemia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"acting_entity","value_text":"mouse-nfe2l2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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