Component
Mouse hematological changes after shikimic-acid feeding
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Small neutrophil, eosinophil and hematocrit increases occurred in the high-dose feeding group.
Experimental context and source evidence
- evidence_access
- Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.
- experimental_contrast
- {"intervention": "High dietary shikimic-acid concentration", "comparator": "Control feed", "endpoint": "Small neutrophil, eosinophil and hematocrit increases occurred in the high-dose feeding group.", "effect_direction": "increase", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- ICR mice; 28-day feeding study.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Measured shifts do not establish beneficial immunity or long-term safety.
- plain_language
- Small neutrophil, eosinophil and hematocrit increases occurred in the high-dose feeding group.
- primary_references
- Pharmacokinetic Profile and Evaluation of Acute and Subchronic Oral Toxicity of Shikimic Acid in Mice. | 2025 | DOI 10.1021/acsomega.5c03740 | PMID 40852254 | https://pubmed.ncbi.nlm.nih.gov/40852254/ | https://doi.org/10.1021/acsomega.5c03740 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12368620/
- source_locator
- Reviewed reference lines 51-51; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 51–51
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · ICR mice; 28-day feeding study. · source_derived_draft · unverified_draft
**Mouse distribution and bounded toxicity observations.** The 2025 mouse study reported intravenous half-lives approximately 0.76–0.85 h at 4–16 mg/kg and oral bioavailability approximately 11.09–20.44% at 50–100 mg/kg. A short plasma half-life does not prove unchanged renal excretion. In a separate 28-day feeding experiment, dietary concentrations were 5.56, 16.67 and 50 g/kg FEED, not mg/kg body weight. High-dose animals had small hematological shifts and lower triglycerides; acute survival through tested doses is not evidence of lifetime human safety. No validated human monocarboxylate-transporter assignment was found in the reviewed sources. [Pharmacokinetic Profile and Evaluation of Acute and Subchronic Oral Toxicity of Shikimic Acid in Mice.](https://pubmed.ncbi.nlm.nih.gov/40852254/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.