Component
Kidney-specific Trpm6-null mouse genotype
Ksp-Cre conditional mouse Trpm6 deletion.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Kidney-restricted Trpm6 deletion did not lower serum Mg or raise urinary Mg in the tested mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence-system
- Ksp-Cre conditional deletion; six-month-old male mice
- experimental_model
- Ksp-Cre conditional deletion; six-month-old male mice
- limitations
- Bone Mg was slightly reduced; this is not proof renal TRPM6 is dispensable under every diet or in humans.
- nutrient_topic
- Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
- organism
- Mouse
- plain_language
- These mice maintained circulating magnesium after kidney-specific TRPM6 loss.
- primary_references
- [chubanov-2016-trpm6] Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival (2016). https://elifesciences.org/articles/20914 DOI: 10.7554/eLife.20914
- tissue
- Kidney; serum and urine
- tissue_or_cell_type
- Kidney; serum and urine
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 936–947
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ksp-Cre conditional deletion; six-month-old male mice · source_derived_draft · unverified_draft
### renal-trpm6-loss-serum-preserved Kidney-restricted Trpm6 deletion did not lower serum Mg or raise urinary Mg in the tested mice. Condition category: machinery_impairment nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: These mice maintained circulating magnesium after kidney-specific TRPM6 loss. organism: Mouse tissue_or_cell_type: Kidney; serum and urine experimental_model: Ksp-Cre conditional deletion; six-month-old male mice limitations: Bone Mg was slightly reduced; this is not proof renal TRPM6 is dispensable under every diet or in humans. evidence-system: Ksp-Cre conditional deletion; six-month-old male mice tissue: Kidney; serum and urine [chubanov-2016-trpm6] Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival (2016). https://elifesciences.org/articles/20914 DOI: 10.7554/eLife.20914
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.