{"id":"32be3c67-3500-5397-ad81-048f23f672b2","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:renal-trpm6-loss-serum-preserved","predicate":"does-not-detectably-alter","statement":"Kidney-restricted Trpm6 deletion did not lower serum Mg or raise urinary Mg in the tested mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"4f932734-43c7-5462-80b9-1c7727ca040d","mechanism_event_label":"These mice maintained circulating magnesium after kidney-specific TRPM6 loss.","subject":{"id":"78da8c8c-a9c1-52e0-9b18-b3bde899466c","slug":"mouse-renal-trpm6-null-genotype","display_name":"Kidney-specific Trpm6-null mouse genotype","entity_type_key":"gene"},"object":{"id":"623a99ab-787c-5d78-8072-72cfcd82008e","slug":"serum-magnesium-concentration","display_name":"Serum magnesium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4f932734-43c7-5462-80b9-1c7727ca040d","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:renal-trpm6-loss-serum-preserved-event","event_type":"biochemical_relationship","label":"These mice maintained circulating magnesium after kidney-specific TRPM6 loss.","description":"Kidney-restricted Trpm6 deletion did not lower serum Mg or raise urinary Mg in the tested mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"877a2fb0-067c-51ca-afea-f63ff16affc8","slug":"trpm6","display_name":"TRPM6","entity_type_key":"protein"},"role":"deleted-channel","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a298b414-0e07-568d-a469-d8aa3e8b8c14","slug":"urinary-magnesium-excretion","display_name":"Urinary magnesium excretion","entity_type_key":"cellular_process"},"role":"measured-endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"78da8c8c-a9c1-52e0-9b18-b3bde899466c","slug":"mouse-renal-trpm6-null-genotype","display_name":"Kidney-specific Trpm6-null mouse genotype","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"623a99ab-787c-5d78-8072-72cfcd82008e","slug":"serum-magnesium-concentration","display_name":"Serum magnesium concentration","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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