Component
Mouse intracellular protein S-nitrosylation
Mouse intracellular protein S-nitrosylation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Reductase deletion increased protein SNO as well as GSNO in the studied mouse system.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/glutathione-research/11260719.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "37ea7e3741c139cea0718d0cdf5e81da638a0f67269277289aa3f715e4c5df61", "start_char": 0, "end_char": 1177, "text_sha256": "37ea7e3741c139cea0718d0cdf5e81da638a0f67269277289aa3f715e4c5df61"}
- experimental_model
- Purification and genetic deletion
- exposure
- GSNO-consuming enzyme identification and deletion
- limitations
- The mouse gene is kept separate from human ADH5. Protein SNO regulation is not identical to direct peroxide removal.
- nutrient_topic
- Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
- organism
- Bacteria, yeast and mouse; mouse findings separated
- plain_language
- Changing the small-molecule pool affected protein modifications.
- primary_references
- [glutathione-p11260719] A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11260719/ DOI: 10.1038/35068596
- tissue_or_cell_type
- Cellular nitrosothiol metabolism
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 1009–1020
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purification and genetic deletion · source_derived_draft · unverified_draft
### glutathione-gsnor-protein-sno Reductase deletion increased protein SNO as well as GSNO in the studied mouse system. Condition category: machinery_impairment nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: Changing the small-molecule pool affected protein modifications. organism: Bacteria, yeast and mouse; mouse findings separated tissue_or_cell_type: Cellular nitrosothiol metabolism experimental_model: Purification and genetic deletion limitations: The mouse gene is kept separate from human ADH5. Protein SNO regulation is not identical to direct peroxide removal. exposure: GSNO-consuming enzyme identification and deletion evidence_span: {"source_cache": "artifacts/glutathione-research/11260719.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "37ea7e3741c139cea0718d0cdf5e81da638a0f67269277289aa3f715e4c5df61", "start_char": 0, "end_char": 1177, "text_sha256": "37ea7e3741c139cea0718d0cdf5e81da638a0f67269277289aa3f715e4c5df61"} [glutathione-p11260719] A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11260719/ DOI: 10.1038/35068596
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.