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(2001). https://pubmed.ncbi.nlm.nih.gov/11260719/ DOI: 10.1038/35068596","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cellular nitrosothiol metabolism","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"9a1f40b7-c93b-51d0-a31d-1d3a6408945e","evidence_kind":"source_excerpt","locator":"Lines 1009-1020","start_line":1009,"end_line":1020,"excerpt":"### glutathione-gsnor-protein-sno\nReductase deletion increased protein SNO as well as GSNO in the studied mouse system.\nCondition category: machinery_impairment\nnutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Changing the small-molecule pool affected protein modifications.\norganism: Bacteria, yeast and mouse; mouse findings separated\ntissue_or_cell_type: Cellular nitrosothiol metabolism\nexperimental_model: Purification and genetic deletion\nlimitations: The mouse gene is kept separate from human ADH5. Protein SNO regulation is not identical to direct peroxide removal.\nexposure: GSNO-consuming enzyme identification and deletion\nevidence_span: {\"source_cache\": \"artifacts/glutathione-research/11260719.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"37ea7e3741c139cea0718d0cdf5e81da638a0f67269277289aa3f715e4c5df61\", \"start_char\": 0, \"end_char\": 1177, \"text_sha256\": \"37ea7e3741c139cea0718d0cdf5e81da638a0f67269277289aa3f715e4c5df61\"}\n[glutathione-p11260719] A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11260719/ DOI: 10.1038/35068596","model_system":"Purification and genetic deletion","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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