Component
Mouse pyruvate dehydrogenase kinase 4 / Pdk4
Mouse pyruvate dehydrogenase kinase 4 / Pdk4. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After 24 hours, mangiferin reduced PDK4 protein abundance in C2C12 cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/24848064.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8cbbc4a9b075ae11f5b88a9929a65c77e6b39870068e320a281bd1802384fec8", "start_char": 30977, "end_char": 31862, "text_sha256": "8e9b4448f5213862fa4c8b78f1d49c9f6b4e6faffb97d818dabbd4117d386dba"}
- experimental_model
- High-fat-fed mice and differentiated C2C12 myotube experiments
- exposure
- 200 or 1000 micromolar mangiferin, 24 hours; Figure 6
- limitations
- Cell exposure well above the parent plasma concentrations reported in the selected human PK study; reduced expression is not direct kinase-binding evidence.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- Mus musculus
- plain_language
- Longer exposure reduced a kinase that restrains PDH.
- primary_references
- [mangiferin-p24848064] Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets. (2014). https://pubmed.ncbi.nlm.nih.gov/24848064/ DOI: 10.2337/db14-0006
- tissue_or_cell_type
- Skeletal muscle and cultured myotubes
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 353–364
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · High-fat-fed mice and differentiated C2C12 myotube experiments · source_derived_draft · unverified_draft
### mangiferin-pdk4 After 24 hours, mangiferin reduced PDK4 protein abundance in C2C12 cells. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Longer exposure reduced a kinase that restrains PDH. organism: Mus musculus tissue_or_cell_type: Skeletal muscle and cultured myotubes experimental_model: High-fat-fed mice and differentiated C2C12 myotube experiments limitations: Cell exposure well above the parent plasma concentrations reported in the selected human PK study; reduced expression is not direct kinase-binding evidence. exposure: 200 or 1000 micromolar mangiferin, 24 hours; Figure 6 evidence_span: {"source_cache": "artifacts/mangiferin-research/24848064.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8cbbc4a9b075ae11f5b88a9929a65c77e6b39870068e320a281bd1802384fec8", "start_char": 30977, "end_char": 31862, "text_sha256": "8e9b4448f5213862fa4c8b78f1d49c9f6b4e6faffb97d818dabbd4117d386dba"} [mangiferin-p24848064] Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets. (2014). https://pubmed.ncbi.nlm.nih.gov/24848064/ DOI: 10.2337/db14-0006
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.