Component
Mouse NAD(P)H quinone dehydrogenase 1 / Nqo1
Mouse NAD(P)H quinone dehydrogenase 1 / Nqo1. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
DIM increased NQO1 mRNA and protein in the mouse fibroblast study.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dim-research/21615272.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8", "start_char": 0, "end_char": 737, "text_sha256": "1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8"}
- experimental_model
- Reporter and gene/protein expression experiments
- exposure
- DIM compared with I3C and sulforaphane
- limitations
- Mouse cells; transcriptional induction does not establish clinical antioxidant benefit or nutrient repletion.
- nutrient_topic
- Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
- organism
- Mouse NIH3T3 fibroblasts
- plain_language
- This downstream enzyme is recorded separately from the Nrf2 regulator.
- primary_references
- [dim-p21615272] 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts. (2011). https://pubmed.ncbi.nlm.nih.gov/21615272/ DOI: 10.3109/10715762.2011.571683
- tissue_or_cell_type
- Nrf2-regulated defense genes
Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 1260–1271
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Reporter and gene/protein expression experiments · source_derived_draft · unverified_draft
### dim-nrf2-mouse-nqo1 DIM increased NQO1 mRNA and protein in the mouse fibroblast study. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: This downstream enzyme is recorded separately from the Nrf2 regulator. organism: Mouse NIH3T3 fibroblasts tissue_or_cell_type: Nrf2-regulated defense genes experimental_model: Reporter and gene/protein expression experiments limitations: Mouse cells; transcriptional induction does not establish clinical antioxidant benefit or nutrient repletion. exposure: DIM compared with I3C and sulforaphane evidence_span: {"source_cache": "artifacts/dim-research/21615272.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8", "start_char": 0, "end_char": 737, "text_sha256": "1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8"} [dim-p21615272] 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts. (2011). https://pubmed.ncbi.nlm.nih.gov/21615272/ DOI: 10.3109/10715762.2011.571683
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.