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(2011). https://pubmed.ncbi.nlm.nih.gov/21615272/ DOI: 10.3109/10715762.2011.571683","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Nrf2-regulated defense genes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"19bbda04-8eb9-55c2-9a05-bf3865ec89a1","evidence_kind":"source_excerpt","locator":"Lines 1260-1271","start_line":1260,"end_line":1271,"excerpt":"### dim-nrf2-mouse-nqo1\nDIM increased NQO1 mRNA and protein in the mouse fibroblast study.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This downstream enzyme is recorded separately from the Nrf2 regulator.\norganism: Mouse NIH3T3 fibroblasts\ntissue_or_cell_type: Nrf2-regulated defense genes\nexperimental_model: Reporter and gene/protein expression experiments\nlimitations: Mouse cells; transcriptional induction does not establish clinical antioxidant benefit or nutrient repletion.\nexposure: DIM compared with I3C and sulforaphane\nevidence_span: {\"source_cache\": \"artifacts/dim-research/21615272.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8\", \"start_char\": 0, \"end_char\": 737, \"text_sha256\": \"1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8\"}\n[dim-p21615272] 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts. 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