Component
Mouse mitochondrial amidoxime-reducing component 2 / Mtarc2
Mouse mitochondrial amidoxime-reducing component 2 / Mtarc2. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The investigators found Marc2 to be the main Marc-family enzyme in mouse liver, with Marc1 contributing relatively little.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/molybdenum-research/38437227.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "152bcc386bca67c8cd4891d284098784ebbdbf9c507f713f96b996bb3c75bd1b", "start_char": 0, "end_char": 1333, "text_sha256": "152bcc386bca67c8cd4891d284098784ebbdbf9c507f713f96b996bb3c75bd1b"}
- experimental_model
- Multi-ancestry exome association, human protein studies and whole-body mouse Marc1 knockout
- exposure
- MARC1 variants and mouse global knockout
- limitations
- Human association and mouse intervention are separate. The knockout null result differs from later published mouse knockout protection.
- nutrient_topic
- Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
- organism
- Human genetics in about 540000 individuals; Mus musculus knockout
- plain_language
- The balance between the two proteins differs across biological settings.
- primary_references
- [mo-p38437227] Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse. (2024). https://pubmed.ncbi.nlm.nih.gov/38437227/ DOI: 10.1371/journal.pgen.1011179
- tissue_or_cell_type
- Liver phenotypes
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 1522–1533
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Multi-ancestry exome association, human protein studies and whole-body mouse Marc1 knockout · source_derived_draft · unverified_draft
### mo-marc2-mouse-dominance The investigators found Marc2 to be the main Marc-family enzyme in mouse liver, with Marc1 contributing relatively little. Condition category: machinery_impairment nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: The balance between the two proteins differs across biological settings. organism: Human genetics in about 540000 individuals; Mus musculus knockout tissue_or_cell_type: Liver phenotypes experimental_model: Multi-ancestry exome association, human protein studies and whole-body mouse Marc1 knockout limitations: Human association and mouse intervention are separate. The knockout null result differs from later published mouse knockout protection. exposure: MARC1 variants and mouse global knockout evidence_span: {"source_cache": "artifacts/molybdenum-research/38437227.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "152bcc386bca67c8cd4891d284098784ebbdbf9c507f713f96b996bb3c75bd1b", "start_char": 0, "end_char": 1333, "text_sha256": "152bcc386bca67c8cd4891d284098784ebbdbf9c507f713f96b996bb3c75bd1b"} [mo-p38437227] Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse. (2024). https://pubmed.ncbi.nlm.nih.gov/38437227/ DOI: 10.1371/journal.pgen.1011179
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.