{"id":"6d440911-c2a5-5c96-91f9-c829d60a6b04","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-marc2-mouse-dominance","predicate":"dominates_assayed_mouse_liver_activity_over","statement":"The investigators found Marc2 to be the main Marc-family enzyme in mouse liver, with Marc1 contributing relatively little.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"38e85d41-3162-563e-8b01-146dec74a744","mechanism_event_label":"The balance between the two proteins differs across biological settings.","subject":{"id":"00ef6a89-f8ff-5c1d-ba95-87f12d52bf93","slug":"mouse-mtarc2","display_name":"Mouse mitochondrial amidoxime-reducing component 2 / Mtarc2","entity_type_key":"protein"},"object":{"id":"9a4caa98-09a8-5d90-a55a-40de766b54e1","slug":"mouse-mtarc1","display_name":"Mouse mitochondrial amidoxime-reducing component 1 / Mtarc1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"38e85d41-3162-563e-8b01-146dec74a744","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-marc2-mouse-dominance-event","event_type":"biochemical_relationship","label":"The balance between the two proteins differs across biological settings.","description":"The investigators found Marc2 to be the main Marc-family enzyme in mouse liver, with Marc1 contributing relatively little.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"00ef6a89-f8ff-5c1d-ba95-87f12d52bf93","slug":"mouse-mtarc2","display_name":"Mouse mitochondrial amidoxime-reducing component 2 / Mtarc2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9a4caa98-09a8-5d90-a55a-40de766b54e1","slug":"mouse-mtarc1","display_name":"Mouse mitochondrial amidoxime-reducing component 1 / Mtarc1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/38437227.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"152bcc386bca67c8cd4891d284098784ebbdbf9c507f713f96b996bb3c75bd1b\", \"start_char\": 0, \"end_char\": 1333, \"text_sha256\": \"152bcc386bca67c8cd4891d284098784ebbdbf9c507f713f96b996bb3c75bd1b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Multi-ancestry exome association, human protein studies and whole-body mouse Marc1 knockout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"MARC1 variants and mouse global knockout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Human association and mouse intervention are separate. 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(2024). https://pubmed.ncbi.nlm.nih.gov/38437227/ DOI: 10.1371/journal.pgen.1011179","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver phenotypes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"dfa85d6e-1522-513d-9d50-be8af4072aa2","evidence_kind":"source_excerpt","locator":"Lines 1522-1533","start_line":1522,"end_line":1533,"excerpt":"### mo-marc2-mouse-dominance\nThe investigators found Marc2 to be the main Marc-family enzyme in mouse liver, with Marc1 contributing relatively little.\nCondition category: machinery_impairment\nnutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The balance between the two proteins differs across biological settings.\norganism: Human genetics in about 540000 individuals; Mus musculus knockout\ntissue_or_cell_type: Liver phenotypes\nexperimental_model: Multi-ancestry exome association, human protein studies and whole-body mouse Marc1 knockout\nlimitations: Human association and mouse intervention are separate. 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