Component
Antitumor immunity in the sulfur/microbiome MR study
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Restriction reduced T-cell abundance and worsened tumor growth and immunotherapy response in immunocompetent mice, while inhibiting growth in immunocompromised mice.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Multiple mouse tumor settings with differing immune competence.
- limitations
- Comparison does not prove the exact cause of every difference from the YTHDF1 study; matched-model replication remains needed.
- nutrient_topic
- L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Methionine
- plain_language
- Tumor and immune-cell effects can point in opposite directions.
- primary_references
- Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37537369/ · DOI 10.1038/s42255-023-00854-3
L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19) · lines 468–474
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Multiple mouse tumor settings with differing immune competence. · source_derived_draft · unverified_draft
## methionine-restriction-immune-harm Tumor and immune-cell effects can point in opposite directions. Restriction reduced T-cell abundance and worsened tumor growth and immunotherapy response in immunocompetent mice, while inhibiting growth in immunocompromised mice. Model: Multiple mouse tumor settings with differing immune competence. Limitations: Comparison does not prove the exact cause of every difference from the YTHDF1 study; matched-model replication remains needed. Evidence access: Primary abstract Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37537369/ · DOI 10.1038/s42255-023-00854-3
Complete structured claim and evidenceSupplementation with an H2S donor, a precursor or methionine restored antitumor immune responses in the tested restriction setting.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Dietary/add-back mouse experiments reported in the primary study.
- limitations
- Donor identity and exposure matter; this is not a human H2S or methionine treatment recommendation.
- nutrient_topic
- L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Methionine
- plain_language
- Restoring sulfur support changed the net tumor response.
- primary_references
- Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37537369/ · DOI 10.1038/s42255-023-00854-3
L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19) · lines 476–482
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Dietary/add-back mouse experiments reported in the primary study. · source_derived_draft · unverified_draft
## methionine-sulfur-rescue Restoring sulfur support changed the net tumor response. Supplementation with an H2S donor, a precursor or methionine restored antitumor immune responses in the tested restriction setting. Model: Dietary/add-back mouse experiments reported in the primary study. Limitations: Donor identity and exposure matter; this is not a human H2S or methionine treatment recommendation. Evidence access: Primary abstract Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37537369/ · DOI 10.1038/s42255-023-00854-3
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.