{"id":"6c8cbf64-185e-5dd8-a3cb-c324e9bf8d5f","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-sulfur-rescue","predicate":"supports_in_donor_experiments","statement":"Supplementation with an H2S donor, a precursor or methionine restored antitumor immune responses in the tested restriction setting.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3ebe29b0-6240-5bbc-87da-34c19c0eb43d","mechanism_event_label":"Restoring sulfur support changed the net tumor response.","subject":{"id":"70cc3ced-8adc-5e76-9750-e1415683455b","slug":"hydrogen-sulfide","display_name":"Hydrogen sulfide / H2S","entity_type_key":"small_molecule"},"object":{"id":"c26571be-73e0-593a-aef3-ea0a2c8dd228","slug":"mouse-mr-sulfur-antitumor-response","display_name":"Antitumor immunity in the sulfur/microbiome MR study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3ebe29b0-6240-5bbc-87da-34c19c0eb43d","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-sulfur-rescue-event","event_type":"observed_relationship","label":"Restoring sulfur support changed the net tumor response.","description":"Supplementation with an H2S donor, a precursor or methionine restored antitumor immune responses in the tested restriction setting.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"70cc3ced-8adc-5e76-9750-e1415683455b","slug":"hydrogen-sulfide","display_name":"Hydrogen sulfide / H2S","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c26571be-73e0-593a-aef3-ea0a2c8dd228","slug":"mouse-mr-sulfur-antitumor-response","display_name":"Antitumor immunity in the sulfur/microbiome MR study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2fa490e6-50cc-5a22-b1ea-af5e128666e4","slug":"experimental-methionine-restriction","display_name":"Experimentally methionine-restricted diet","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary/add-back mouse experiments reported in the primary study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Donor identity and exposure matter; this is not a human H2S or methionine treatment recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Restoring sulfur support changed the net tumor response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37537369/ · DOI 10.1038/s42255-023-00854-3","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6aa736cc-b07f-5813-95ca-5fdcbbdf88bf","evidence_kind":"source_excerpt","locator":"Lines 476-482","start_line":476,"end_line":482,"excerpt":"## methionine-sulfur-rescue\nRestoring sulfur support changed the net tumor response.\nSupplementation with an H2S donor, a precursor or methionine restored antitumor immune responses in the tested restriction setting.\nModel: Dietary/add-back mouse experiments reported in the primary study.\nLimitations: Donor identity and exposure matter; this is not a human H2S or methionine treatment recommendation.\nEvidence access: Primary abstract\nMethionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37537369/ · DOI 10.1038/s42255-023-00854-3","model_system":"Dietary/add-back mouse experiments reported in the primary study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d969b004-ccc2-5bb4-9109-8ac649137ad1","stable_key":"import-41a89233-da9a-5b7b-9c18-e19bbadcfe2d","title":"L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f1c706ef72932eed85df234b6c3304158d503d626a63c69b02a453c162700d26","revision_id":"549035e0-3a72-550a-8a55-e8c5baa51b0d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}