Component
Mouse LOX and LOXL enzyme activity
Mouse LOX and LOXL enzyme activity. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Atp7a silencing reduced LOX/LOXL activity in mouse mammary and lung carcinoma models.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/copper-research/30890638.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bc966add777f73d031bc34724fb8a07c6f4df2493086e13df7ae4521dee74816", "start_char": 0, "end_char": 1001, "text_sha256": "bc966add777f73d031bc34724fb8a07c6f4df2493086e13df7ae4521dee74816"}
- experimental_model
- Atp7a silencing and orthotopic tumor experiments
- exposure
- Atp7a silencing
- limitations
- Tumor models are not evidence that dietary copper causes cancer or that copper restriction treats it; the human survival component was associative.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Mouse; separate human survival association
- plain_language
- The copper delivery pump helps activate extracellular cross-linking enzymes.
- primary_references
- [copper-p30890638] ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis. (2019). https://pubmed.ncbi.nlm.nih.gov/30890638/ DOI: 10.1073/pnas.1817473116
- tissue_or_cell_type
- 4T1 mammary carcinoma and Lewis lung carcinoma
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 923–934
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Atp7a silencing and orthotopic tumor experiments · source_derived_draft · unverified_draft
### copper-atp7a-lox-loading Atp7a silencing reduced LOX/LOXL activity in mouse mammary and lung carcinoma models. Condition category: normal nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: The copper delivery pump helps activate extracellular cross-linking enzymes. organism: Mouse; separate human survival association tissue_or_cell_type: 4T1 mammary carcinoma and Lewis lung carcinoma experimental_model: Atp7a silencing and orthotopic tumor experiments limitations: Tumor models are not evidence that dietary copper causes cancer or that copper restriction treats it; the human survival component was associative. exposure: Atp7a silencing evidence_span: {"source_cache": "artifacts/copper-research/30890638.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bc966add777f73d031bc34724fb8a07c6f4df2493086e13df7ae4521dee74816", "start_char": 0, "end_char": 1001, "text_sha256": "bc966add777f73d031bc34724fb8a07c6f4df2493086e13df7ae4521dee74816"} [copper-p30890638] ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis. (2019). https://pubmed.ncbi.nlm.nih.gov/30890638/ DOI: 10.1073/pnas.1817473116
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.