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(2019). https://pubmed.ncbi.nlm.nih.gov/30890638/ DOI: 10.1073/pnas.1817473116","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"4T1 mammary carcinoma and Lewis lung carcinoma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"20a6fc2f-f2ea-5bbb-8ff9-4ce37c4dc051","evidence_kind":"source_excerpt","locator":"Lines 923-934","start_line":923,"end_line":934,"excerpt":"### copper-atp7a-lox-loading\nAtp7a silencing reduced LOX/LOXL activity in mouse mammary and lung carcinoma models.\nCondition category: normal\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The copper delivery pump helps activate extracellular cross-linking enzymes.\norganism: Mouse; separate human survival association\ntissue_or_cell_type: 4T1 mammary carcinoma and Lewis lung carcinoma\nexperimental_model: Atp7a silencing and orthotopic tumor experiments\nlimitations: Tumor models are not evidence that dietary copper causes cancer or that copper restriction treats it; the human survival component was associative.\nexposure: Atp7a silencing\nevidence_span: {\"source_cache\": \"artifacts/copper-research/30890638.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"bc966add777f73d031bc34724fb8a07c6f4df2493086e13df7ae4521dee74816\", \"start_char\": 0, \"end_char\": 1001, \"text_sha256\": \"bc966add777f73d031bc34724fb8a07c6f4df2493086e13df7ae4521dee74816\"}\n[copper-p30890638] ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis. 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