Component
Liver and kidney injury profile in female ICR mice
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Oral hydroethanolic Moringa leaf extract caused biochemical and histological liver and kidney injury in female ICR mice after a single 2000 mg/kg dose and during 28-day dosing up to 1000 mg/kg/day.
Experimental context and source evidence
- dose
- 2000 mg/kg once or 125-1000 mg/kg/day hydroethanolic extract
- duration
- Acute or 28 days
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Female ICR mice
- limitations
- These concentrated high-dose mouse exposures do not define risk from culinary leaves, tea or labeled human supplement doses.
- nutrient_topic
- Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Moringa oleifera
- organism
- Female ICR mice
- plain_language
- Oral hydroethanolic Moringa leaf extract caused biochemical and histological liver and kidney injury in female ICR mice after a single 2000 mg/kg dose and during 28-day dosing up to 1000 mg/kg/day.
- primary_references
- Moringa oleifera hydorethanolic leaf extract induced acute and sub-acute hepato-nephrotoxicity in female ICR-mice. (2021). https://pubmed.ncbi.nlm.nih.gov/34886737/ DOI: 10.1177/00368504211004272
- route
- Oral gavage
- tissue
- Hematology, enzymes and liver/kidney histology
Moringa oleifera: mechanism of action and interactions (2026-09-20) · lines 299–308
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Female ICR mice · source_derived_draft · unverified_draft
## moringa-high-dose-extract-toxicity Oral hydroethanolic Moringa leaf extract caused biochemical and histological liver and kidney injury in female ICR mice after a single 2000 mg/kg dose and during 28-day dosing up to 1000 mg/kg/day. Model/species: Female ICR mice Tissue/system: Hematology, enzymes and liver/kidney histology Exposure: 2000 mg/kg once or 125-1000 mg/kg/day hydroethanolic extract Route: Oral gavage Duration: Acute or 28 days Limits: These concentrated high-dose mouse exposures do not define risk from culinary leaves, tea or labeled human supplement doses. Primary reference: Moringa oleifera hydorethanolic leaf extract induced acute and sub-acute hepato-nephrotoxicity in female ICR-mice. (2021). https://pubmed.ncbi.nlm.nih.gov/34886737/ DOI: 10.1177/00368504211004272 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.