Component
Survival of Lias-null mouse embryos
Survival of Lias-null mouse embryos. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lias-null mouse embryos died before embryonic day 9.5.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/ala-research/16135825.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1750e4eb7b27e8b28bf973a3683d88c6ad9d639acc10f3f4c5df6077fb384da", "start_char": 0, "end_char": 1393, "text_sha256": "b1750e4eb7b27e8b28bf973a3683d88c6ad9d639acc10f3f4c5df6077fb384da"}
- experimental_model
- Targeted Lias knockout and maternal supplementation
- exposure
- Lias-null embryos; high maternal lipoic-acid intake
- limitations
- Embryonic genetic loss is not a dietary depletion model in humans.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Mouse
- plain_language
- The developing embryo required its own cofactor-synthesis machinery.
- primary_references
- [ala-p16135825] Endogenous production of lipoic acid is essential for mouse development. (2005). https://pubmed.ncbi.nlm.nih.gov/16135825/ DOI: 10.1128/mcb.25.18.8387-8392.2005
- tissue_or_cell_type
- Embryos and pregnant dams
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 585–596
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted Lias knockout and maternal supplementation · source_derived_draft · unverified_draft
### ala-lias-embryonic-loss Lias-null mouse embryos died before embryonic day 9.5. Condition category: machinery_impairment nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The developing embryo required its own cofactor-synthesis machinery. organism: Mouse tissue_or_cell_type: Embryos and pregnant dams experimental_model: Targeted Lias knockout and maternal supplementation limitations: Embryonic genetic loss is not a dietary depletion model in humans. exposure: Lias-null embryos; high maternal lipoic-acid intake evidence_span: {"source_cache": "artifacts/ala-research/16135825.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1750e4eb7b27e8b28bf973a3683d88c6ad9d639acc10f3f4c5df6077fb384da", "start_char": 0, "end_char": 1393, "text_sha256": "b1750e4eb7b27e8b28bf973a3683d88c6ad9d639acc10f3f4c5df6077fb384da"} [ala-p16135825] Endogenous production of lipoic acid is essential for mouse development. (2005). https://pubmed.ncbi.nlm.nih.gov/16135825/ DOI: 10.1128/mcb.25.18.8387-8392.2005
Complete structured claim and evidenceThe tested high maternal lipoic-acid supplementation did not rescue Lias-null embryos.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/ala-research/16135825.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1750e4eb7b27e8b28bf973a3683d88c6ad9d639acc10f3f4c5df6077fb384da", "start_char": 0, "end_char": 1393, "text_sha256": "b1750e4eb7b27e8b28bf973a3683d88c6ad9d639acc10f3f4c5df6077fb384da"}
- experimental_model
- Targeted Lias knockout and maternal supplementation
- exposure
- Lias-null embryos; high maternal lipoic-acid intake
- limitations
- Embryonic genetic loss is not a dietary depletion model in humans.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Mouse
- plain_language
- Maternal intake did not bypass the embryo’s missing synthesis enzyme.
- primary_references
- [ala-p16135825] Endogenous production of lipoic acid is essential for mouse development. (2005). https://pubmed.ncbi.nlm.nih.gov/16135825/ DOI: 10.1128/mcb.25.18.8387-8392.2005
- tissue_or_cell_type
- Embryos and pregnant dams
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 598–609
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted Lias knockout and maternal supplementation · source_derived_draft · unverified_draft
### ala-maternal-lipoate-no-rescue The tested high maternal lipoic-acid supplementation did not rescue Lias-null embryos. Condition category: machinery_impairment nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Maternal intake did not bypass the embryo’s missing synthesis enzyme. organism: Mouse tissue_or_cell_type: Embryos and pregnant dams experimental_model: Targeted Lias knockout and maternal supplementation limitations: Embryonic genetic loss is not a dietary depletion model in humans. exposure: Lias-null embryos; high maternal lipoic-acid intake evidence_span: {"source_cache": "artifacts/ala-research/16135825.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1750e4eb7b27e8b28bf973a3683d88c6ad9d639acc10f3f4c5df6077fb384da", "start_char": 0, "end_char": 1393, "text_sha256": "b1750e4eb7b27e8b28bf973a3683d88c6ad9d639acc10f3f4c5df6077fb384da"} [ala-p16135825] Endogenous production of lipoic acid is essential for mouse development. (2005). https://pubmed.ncbi.nlm.nih.gov/16135825/ DOI: 10.1128/mcb.25.18.8387-8392.2005
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.