Component
Intestine-specific Slc52a3-null mouse genotype
Conditional deletion of Slc52a3 in intestinal epithelium.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Intestine-specific Slc52a3 deletion severely reduced carrier-mediated riboflavin uptake in mouse jejunal/colonic loops and isolated enterocytes.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_location
- Effect of loss of RFVT-3 on intestinal RF uptake
- experimental_model
- Conditional knockout with in vivo loops and isolated enterocytes
- exposure
- Intestinal Slc52a3 deletion versus littermate controls.
- limitations
- Residual uptake and species differences limit generalization.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Mus musculus
- plain_language
- Loss of intestinal RFVT3 restricts riboflavin absorption.
- primary_references
- [transport-intestinal-ko-2016] Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption. (2016). https://pubmed.ncbi.nlm.nih.gov/26660539/ DOI: 10.1152/ajpgi.00340.2015
- tissue_or_cell_type
- Jejunum, colon and isolated intestinal epithelium
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 267–278
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conditional knockout with in vivo loops and isolated enterocytes · source_derived_draft · unverified_draft
### transport-intestinal-ko-uptake Intestine-specific Slc52a3 deletion severely reduced carrier-mediated riboflavin uptake in mouse jejunal/colonic loops and isolated enterocytes. Condition category: machinery_impairment nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Loss of intestinal RFVT3 restricts riboflavin absorption. organism: Mus musculus tissue_or_cell_type: Jejunum, colon and isolated intestinal epithelium experimental_model: Conditional knockout with in vivo loops and isolated enterocytes limitations: Residual uptake and species differences limit generalization. exposure: Intestinal Slc52a3 deletion versus littermate controls. evidence_location: Effect of loss of RFVT-3 on intestinal RF uptake [transport-intestinal-ko-2016] Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption. (2016). https://pubmed.ncbi.nlm.nih.gov/26660539/ DOI: 10.1152/ajpgi.00340.2015
Complete structured claim and evidence
Where it participates (unsigned role)
Pharmacological riboflavin supplementation corrected growth retardation in the intestinal Slc52a3 conditional-knockout mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_location
- Effect of RF supplementation on animal phenotype
- experimental_model
- Riboflavin supplementation in conditional-knockout mice
- exposure
- Pharmacological riboflavin supplementation as described by the study.
- limitations
- The rescue does not establish the residual entry route or an effective human dose.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Mus musculus
- plain_language
- Higher riboflavin exposure rescued growth in this transporter-loss mouse model.
- primary_references
- [transport-intestinal-ko-2016] Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption. (2016). https://pubmed.ncbi.nlm.nih.gov/26660539/ DOI: 10.1152/ajpgi.00340.2015
- tissue_or_cell_type
- Whole-animal postnatal growth
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 280–291
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Riboflavin supplementation in conditional-knockout mice · source_derived_draft · unverified_draft
### transport-intestinal-ko-growth-rescue Pharmacological riboflavin supplementation corrected growth retardation in the intestinal Slc52a3 conditional-knockout mice. Condition category: machinery_impairment nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Higher riboflavin exposure rescued growth in this transporter-loss mouse model. organism: Mus musculus tissue_or_cell_type: Whole-animal postnatal growth experimental_model: Riboflavin supplementation in conditional-knockout mice limitations: The rescue does not establish the residual entry route or an effective human dose. exposure: Pharmacological riboflavin supplementation as described by the study. evidence_location: Effect of RF supplementation on animal phenotype [transport-intestinal-ko-2016] Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption. (2016). https://pubmed.ncbi.nlm.nih.gov/26660539/ DOI: 10.1152/ajpgi.00340.2015
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.