Component
Forskolin-induced inhibition of mouse ileal contractility
Experimental species, exposure and limitations are retained on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Indicaxanthin enhanced the inhibitory effect of forskolin on mouse ileal mechanical activity.
Experimental context and source evidence
- dose
- Indicaxanthin; forskolin, IBMX and other pharmacological probes, exact concentrations not in accessed abstract
- duration
- Acute responses; exact interval not in accessed abstract
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Isolated mouse ileal longitudinal muscle
- limitations
- PDE involvement is inferred pharmacologically, not established by an isoform-specific binding or purified-enzyme assay; no clinical motility treatment is tested.
- nutrient_topic
- Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved. · Indicaxanthin
- organism
- Isolated mouse ileal longitudinal muscle
- plain_language
- Indicaxanthin enhanced the inhibitory effect of forskolin on mouse ileal mechanical activity.
- primary_references
- Inhibitory effects of indicaxanthin on mouse ileal contractility: analysis of the mechanism of action. (2011). https://pubmed.ncbi.nlm.nih.gov/21371457/ DOI: 10.1016/j.ejphar.2011.02.034
- route
- Ex vivo organ-bath addition
- tissue
- Organ-bath smooth muscle
Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 107–116
Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. Not publisher full text. · supports · Isolated mouse ileal longitudinal muscle · source_derived_draft · unverified_draft
## indicaxanthin-ileal-forskolin Indicaxanthin enhanced the inhibitory effect of forskolin on mouse ileal mechanical activity. Model/species: Isolated mouse ileal longitudinal muscle Tissue: Organ-bath smooth muscle Exposure: Indicaxanthin; forskolin, IBMX and other pharmacological probes, exact concentrations not in accessed abstract Route: Ex vivo organ-bath addition Duration: Acute responses; exact interval not in accessed abstract Limits: PDE involvement is inferred pharmacologically, not established by an isoform-specific binding or purified-enzyme assay; no clinical motility treatment is tested. Primary reference: Inhibitory effects of indicaxanthin on mouse ileal contractility: analysis of the mechanism of action. (2011). https://pubmed.ncbi.nlm.nih.gov/21371457/ DOI: 10.1016/j.ejphar.2011.02.034 Access: Primary PubMed abstract.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.