{"id":"7c8fa08d-0f02-56aa-af32-39e9887b7719","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-ileal-forskolin","predicate":"potentiates","statement":"Indicaxanthin enhanced the inhibitory effect of forskolin on mouse ileal mechanical activity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7fd0e5fb-ca8e-5512-bc19-f63c338dda5e","mechanism_event_label":"Indicaxanthin enhanced the inhibitory effect of forskolin on mouse ileal mechanical activity.","subject":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"object":{"id":"bf6f6d56-bcdf-563a-a124-32adbf272ca4","slug":"mouse-ileal-forskolin-relaxation","display_name":"Forskolin-induced inhibition of mouse ileal contractility","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7fd0e5fb-ca8e-5512-bc19-f63c338dda5e","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-ileal-forskolin-event","event_type":"observed_relationship","label":"Indicaxanthin enhanced the inhibitory effect of forskolin on mouse ileal mechanical activity.","description":"Indicaxanthin enhanced the inhibitory effect of forskolin on mouse ileal mechanical activity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bf6f6d56-bcdf-563a-a124-32adbf272ca4","slug":"mouse-ileal-forskolin-relaxation","display_name":"Forskolin-induced inhibition of mouse ileal contractility","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1a29cb8b-2916-5c74-a3d7-b2ae61fd37de","slug":"forskolin","display_name":"Forskolin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Indicaxanthin; forskolin, IBMX and other pharmacological probes, exact concentrations not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute responses; exact interval not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated mouse ileal longitudinal muscle","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"PDE involvement is inferred pharmacologically, not established by an isoform-specific binding or purified-enzyme assay; no clinical motility treatment is tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved.","comparator":null,"unit":null,"notes":"","entity":{"slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Isolated mouse ileal longitudinal muscle","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Indicaxanthin enhanced the inhibitory effect of forskolin on mouse ileal mechanical activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibitory effects of indicaxanthin on mouse ileal contractility: analysis of the mechanism of action. (2011). https://pubmed.ncbi.nlm.nih.gov/21371457/ DOI: 10.1016/j.ejphar.2011.02.034","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Ex vivo organ-bath addition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Organ-bath smooth muscle","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"53198171-6fc4-5524-967d-68fca6b6e08b","evidence_kind":"source_excerpt","locator":"Lines 107-116","start_line":107,"end_line":116,"excerpt":"## indicaxanthin-ileal-forskolin\nIndicaxanthin enhanced the inhibitory effect of forskolin on mouse ileal mechanical activity.\nModel/species: Isolated mouse ileal longitudinal muscle\nTissue: Organ-bath smooth muscle\nExposure: Indicaxanthin; forskolin, IBMX and other pharmacological probes, exact concentrations not in accessed abstract\nRoute: Ex vivo organ-bath addition\nDuration: Acute responses; exact interval not in accessed abstract\nLimits: PDE involvement is inferred pharmacologically, not established by an isoform-specific binding or purified-enzyme assay; no clinical motility treatment is tested.\nPrimary reference: Inhibitory effects of indicaxanthin on mouse ileal contractility: analysis of the mechanism of action. (2011). https://pubmed.ncbi.nlm.nih.gov/21371457/ DOI: 10.1016/j.ejphar.2011.02.034\nAccess: Primary PubMed abstract.","model_system":"Isolated mouse ileal longitudinal muscle","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; original paraphrase with primary citation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"18b7303c-98b7-54cb-ae8e-a8c6257657b1","stable_key":"import-c94a9824-35fb-523c-b421-dc7341218dcb","title":"Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. 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