Component
Cortical TUNEL-positive cells in high-fat-diet-fed mice
Experimental species, exposure and limitations are retained on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Oral indicaxanthin reduced cortical TUNEL-positive cells in high-fat-diet-fed male mice.
Experimental context and source evidence
- dose
- High-fat diet for 10 weeks then indicaxanthin for 4 weeks; abstract reports 0.86 mg/kg/day, methods state 0.4 mg/kg twice daily
- duration
- 4 treatment weeks; eight mice/group
- evidence_access
- Primary open full text, relevant results/methods and PubMed metadata.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Male mice with diet-induced obesity
- limitations
- Dose wording differs between abstract and methods and is preserved unresolved. Changes in microbial abundance do not demonstrate measured SCFA production or microbiota-mediated causation of brain changes. Article assigned 2026 issue; earlier online indexing retained in PubMed.
- nutrient_topic
- Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved. · Indicaxanthin
- organism
- Male mice with diet-induced obesity
- plain_language
- Oral indicaxanthin reduced cortical TUNEL-positive cells in high-fat-diet-fed male mice.
- primary_references
- Positive impact of indicaxanthin from Opuntia ficus-indica fruit on high-fat diet-induced neuronal damage and gut microbiota dysbiosis. (2026). https://pubmed.ncbi.nlm.nih.gov/39314163/ DOI: 10.4103/NRR.NRR-D-23-02039
- route
- Oral indicaxanthin in water
- tissue
- Cerebral cortex and gut microbiota
Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 470–479
Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. Not publisher full text. · supports · Male mice with diet-induced obesity · source_derived_draft · unverified_draft
## indicaxanthin-hfd-cortical-cell-death Oral indicaxanthin reduced cortical TUNEL-positive cells in high-fat-diet-fed male mice. Model/species: Male mice with diet-induced obesity Tissue: Cerebral cortex and gut microbiota Exposure: High-fat diet for 10 weeks then indicaxanthin for 4 weeks; abstract reports 0.86 mg/kg/day, methods state 0.4 mg/kg twice daily Route: Oral indicaxanthin in water Duration: 4 treatment weeks; eight mice/group Limits: Dose wording differs between abstract and methods and is preserved unresolved. Changes in microbial abundance do not demonstrate measured SCFA production or microbiota-mediated causation of brain changes. Article assigned 2026 issue; earlier online indexing retained in PubMed. Primary reference: Positive impact of indicaxanthin from Opuntia ficus-indica fruit on high-fat diet-induced neuronal damage and gut microbiota dysbiosis. (2026). https://pubmed.ncbi.nlm.nih.gov/39314163/ DOI: 10.4103/NRR.NRR-D-23-02039 Access: Primary open full text, relevant results/methods and PubMed metadata.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.