Component
Mouse gut micronucleus frequency
Experimental model, exposure and limitations remain on each linked record.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Tartrazine did not increase gut micronucleus frequency under the tested acute mouse protocol.
Experimental context and source evidence
- dose
- Tartrazine doses up to 2000 mg/kg body weight
- duration
- Doses 24 h apart
- evidence_access
- Primary PubMed abstract; unrecovered method details explicitly retained.
- evidence_scope
- literature_reviewed; source-specific experimental curation
- experimental_model
- Mice in the in vivo gut micronucleus assay
- limitations
- No micronucleus increase under this protocol does not exclude transient DNA damage, other endpoints, or chronic effects. Co-studied dyes and their metabolites are not pooled as tartrazine-specific results.
- nutrient_topic
- Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits. · Tartrazine
- organism
- Mice in the in vivo gut micronucleus assay
- plain_language
- Tartrazine did not increase gut micronucleus frequency under the tested acute mouse protocol.
- primary_references
- Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice. (2009). https://pubmed.ncbi.nlm.nih.gov/19095036/ DOI: 10.1016/j.fct.2008.11.034
- route
- Oral gavage twice
- tissue
- Intestinal genotoxicity endpoint
Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 347–356
Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Mice in the in vivo gut micronucleus assay · source_derived_draft · unverified_draft
## tartrazine-gut-micronucleus-null Tartrazine did not increase gut micronucleus frequency under the tested acute mouse protocol. Model/species: Mice in the in vivo gut micronucleus assay Tissue: Intestinal genotoxicity endpoint Exposure: Tartrazine doses up to 2000 mg/kg body weight Route: Oral gavage twice Duration: Doses 24 h apart Limits: No micronucleus increase under this protocol does not exclude transient DNA damage, other endpoints, or chronic effects. Co-studied dyes and their metabolites are not pooled as tartrazine-specific results. Primary reference: Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice. (2009). https://pubmed.ncbi.nlm.nih.gov/19095036/ DOI: 10.1016/j.fct.2008.11.034 Access: Primary PubMed abstract; unrecovered method details explicitly retained.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.