Component
GLP-1 secretion from mouse GLUTag cells
Species, exposure, manipulation and evidence limits are specified on each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Fructose stimulated GLP-1 secretion in mouse GLUTag cells with a reported EC50 of 0.155 mM.
Experimental context and source evidence
- dose
- Fructose concentration series, EC50 0.155 mM; blocker experiment 10 mM fructose plus 340 micromolar diazoxide
- duration
- 2 h
- evidence_access
- Primary full-text methods/results and metadata inspected.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- Mouse GLUTag enteroendocrine cell line
- exposure_scope
- Isolated fructose / drug-peptide assay
- limitations
- Pharmacological channel control in a cell line does not establish a human drug-food interaction or a reason to consume fructose therapeutically.
- nutrient_topic
- HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished. · High-Fructose Corn Syrup / HFCS
- organism
- Mouse GLUTag enteroendocrine cell line
- plain_language
- Fructose stimulated GLP-1 secretion in mouse GLUTag cells with a reported EC50 of 0.155 mM.
- primary_references
- Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. (2014). https://pubmed.ncbi.nlm.nih.gov/24525020/ DOI: 10.1152/ajpgi.00372.2013
- route
- In vitro sugar and drug exposure
- tissue
- GLP-1 secretion assay
High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20) · lines 473–483
Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Mouse GLUTag enteroendocrine cell line · source_derived_draft · unverified_draft
## hfcs-cell-glp1 Fructose stimulated GLP-1 secretion in mouse GLUTag cells with a reported EC50 of 0.155 mM. Model/species: Mouse GLUTag enteroendocrine cell line Tissue: GLP-1 secretion assay Exposure: Fructose concentration series, EC50 0.155 mM; blocker experiment 10 mM fructose plus 340 micromolar diazoxide Route: In vitro sugar and drug exposure Duration: 2 h Exposure scope: Isolated fructose / drug-peptide assay Limits: Pharmacological channel control in a cell line does not establish a human drug-food interaction or a reason to consume fructose therapeutically. Reference: Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. (2014). https://pubmed.ncbi.nlm.nih.gov/24525020/ DOI: 10.1152/ajpgi.00372.2013 Access: Primary full-text methods/results and metadata inspected.
Complete structured claim and evidenceDiazoxide at 340 micromolar abolished fructose-stimulated GLP-1 secretion in GLUTag cells.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- dose
- Fructose concentration series, EC50 0.155 mM; blocker experiment 10 mM fructose plus 340 micromolar diazoxide
- duration
- 2 h
- evidence_access
- Primary full-text methods/results and metadata inspected.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- Mouse GLUTag enteroendocrine cell line
- exposure_scope
- Isolated fructose / drug-peptide assay
- limitations
- Pharmacological channel control in a cell line does not establish a human drug-food interaction or a reason to consume fructose therapeutically.
- nutrient_topic
- HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished. · High-Fructose Corn Syrup / HFCS
- organism
- Mouse GLUTag enteroendocrine cell line
- plain_language
- Diazoxide at 340 micromolar abolished fructose-stimulated GLP-1 secretion in GLUTag cells.
- primary_references
- Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. (2014). https://pubmed.ncbi.nlm.nih.gov/24525020/ DOI: 10.1152/ajpgi.00372.2013
- route
- In vitro sugar and drug exposure
- tissue
- GLP-1 secretion assay
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20) · lines 485–495
Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Mouse GLUTag enteroendocrine cell line · source_derived_draft · unverified_draft
## hfcs-diazoxide Diazoxide at 340 micromolar abolished fructose-stimulated GLP-1 secretion in GLUTag cells. Model/species: Mouse GLUTag enteroendocrine cell line Tissue: GLP-1 secretion assay Exposure: Fructose concentration series, EC50 0.155 mM; blocker experiment 10 mM fructose plus 340 micromolar diazoxide Route: In vitro sugar and drug exposure Duration: 2 h Exposure scope: Isolated fructose / drug-peptide assay Limits: Pharmacological channel control in a cell line does not establish a human drug-food interaction or a reason to consume fructose therapeutically. Reference: Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. (2014). https://pubmed.ncbi.nlm.nih.gov/24525020/ DOI: 10.1152/ajpgi.00372.2013 Access: Primary full-text methods/results and metadata inspected.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.