Component
Mouse ferrochelatase / Fech
Mouse ferrochelatase / Fech. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Fech interacted with both Mfrn1 and Abcb10 in the studied erythroid systems.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/iron-research/20427704.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4f3b1c37151557d4d888126ba888dd95391254c5e40d1c3576f0520eed7517c", "start_char": 0, "end_char": 1059, "text_sha256": "a4f3b1c37151557d4d888126ba888dd95391254c5e40d1c3576f0520eed7517c"}
- experimental_model
- Affinity purification and immunoprecipitation
- exposure
- Mfrn1, Abcb10 and Fech interaction analysis
- limitations
- Physical association supports coordination; direct substrate channeling was not separately proven.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Mouse erythroleukemia cells and heterologous HEK293 expression
- plain_language
- Iron import and the final heme-synthesis enzyme can be physically organized together.
- primary_references
- [iron-p20427704] Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. (2010). https://pubmed.ncbi.nlm.nih.gov/20427704/ DOI: 10.1182/blood-2009-12-259614
- tissue_or_cell_type
- Mitochondrial heme-synthesis machinery
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 498–509
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Affinity purification and immunoprecipitation · source_derived_draft · unverified_draft
### iron-mitoferrin-fech-complex Fech interacted with both Mfrn1 and Abcb10 in the studied erythroid systems. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iron import and the final heme-synthesis enzyme can be physically organized together. organism: Mouse erythroleukemia cells and heterologous HEK293 expression tissue_or_cell_type: Mitochondrial heme-synthesis machinery experimental_model: Affinity purification and immunoprecipitation limitations: Physical association supports coordination; direct substrate channeling was not separately proven. exposure: Mfrn1, Abcb10 and Fech interaction analysis evidence_span: {"source_cache": "artifacts/iron-research/20427704.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a4f3b1c37151557d4d888126ba888dd95391254c5e40d1c3576f0520eed7517c", "start_char": 0, "end_char": 1059, "text_sha256": "a4f3b1c37151557d4d888126ba888dd95391254c5e40d1c3576f0520eed7517c"} [iron-p20427704] Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. (2010). https://pubmed.ncbi.nlm.nih.gov/20427704/ DOI: 10.1182/blood-2009-12-259614
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.