Component
Mouse enterocyte-specific Slc39a5 knockout genotype
Engineered conditional loss-of-function genotype, not the wild-type gene. Induced intestinal deletion of mouse Slc39a5.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Enterocyte-specific Zip5 deletion increased pancreatic zinc in mice eating a zinc-adequate diet.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Conditional intestinal knockout with tissue elemental analysis
- exposure
- Induced enterocyte deletion on zinc-adequate chow.
- limitations
- This measured redistribution supports but does not directly quantify the proposed blood-to-enterocyte-to-lumen excretion route.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Mus musculus
- plain_language
- Removing intestinal ZIP5 changed where zinc accumulated, increasing the pancreatic pool.
- primary_references
- [zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149
- tissue_or_cell_type
- Intestinal enterocytes; pancreatic zinc endpoint
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 388–399
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conditional intestinal knockout with tissue elemental analysis · source_derived_draft · unverified_draft
### zinc-trans-intestinal-zip5-pancreas-zinc Enterocyte-specific Zip5 deletion increased pancreatic zinc in mice eating a zinc-adequate diet. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing intestinal ZIP5 changed where zinc accumulated, increasing the pancreatic pool. organism: Mus musculus tissue_or_cell_type: Intestinal enterocytes; pancreatic zinc endpoint experimental_model: Conditional intestinal knockout with tissue elemental analysis limitations: This measured redistribution supports but does not directly quantify the proposed blood-to-enterocyte-to-lumen excretion route. exposure: Induced enterocyte deletion on zinc-adequate chow. cross_nutrient: false [zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.