{"id":"dff7e088-eeba-5adc-8cef-313b30c740aa","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-intestinal-zip5-pancreas-zinc","predicate":"increases","statement":"Enterocyte-specific Zip5 deletion increased pancreatic zinc in mice eating a zinc-adequate diet.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8845b3fd-b251-59e8-9f90-12590961aac1","mechanism_event_label":"Removing intestinal ZIP5 changed where zinc accumulated, increasing the pancreatic pool.","subject":{"id":"eb8f2854-0339-53a4-9007-58361d9b877f","slug":"mouse-enterocyte-slc39a5-knockout","display_name":"Mouse enterocyte-specific Slc39a5 knockout genotype","entity_type_key":"gene"},"object":{"id":"584b3845-250f-5700-b66f-cd0d5bda7297","slug":"pancreatic-zinc-content","display_name":"Pancreatic total zinc content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8845b3fd-b251-59e8-9f90-12590961aac1","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-intestinal-zip5-pancreas-zinc-event","event_type":"biochemical_relationship","label":"Removing intestinal ZIP5 changed where zinc accumulated, increasing the pancreatic pool.","description":"Enterocyte-specific Zip5 deletion increased pancreatic zinc in mice eating a zinc-adequate diet.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5d71153b-6474-5bc7-89ff-666b940683da","slug":"mouse-slc39a5","display_name":"Mouse ZIP5 (Slc39a5)","entity_type_key":"protein"},"role":"deleted_transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"measured_elemental_pool","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"eb8f2854-0339-53a4-9007-58361d9b877f","slug":"mouse-enterocyte-slc39a5-knockout","display_name":"Mouse enterocyte-specific Slc39a5 knockout genotype","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"584b3845-250f-5700-b66f-cd0d5bda7297","slug":"pancreatic-zinc-content","display_name":"Pancreatic total zinc content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Conditional intestinal knockout with tissue elemental analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Induced enterocyte deletion on zinc-adequate chow.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This measured redistribution supports but does not directly quantify the proposed blood-to-enterocyte-to-lumen excretion route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Removing intestinal ZIP5 changed where zinc accumulated, increasing the pancreatic pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal enterocytes; pancreatic zinc endpoint","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"fbe0c5c6-3b2c-5421-8728-bf5f90792462","evidence_kind":"source_excerpt","locator":"Lines 388-399","start_line":388,"end_line":399,"excerpt":"### zinc-trans-intestinal-zip5-pancreas-zinc\nEnterocyte-specific Zip5 deletion increased pancreatic zinc in mice eating a zinc-adequate diet.\nCondition category: machinery_impairment\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Removing intestinal ZIP5 changed where zinc accumulated, increasing the pancreatic pool.\norganism: Mus musculus\ntissue_or_cell_type: Intestinal enterocytes; pancreatic zinc endpoint\nexperimental_model: Conditional intestinal knockout with tissue elemental analysis\nlimitations: This measured redistribution supports but does not directly quantify the proposed blood-to-enterocyte-to-lumen excretion route.\nexposure: Induced enterocyte deletion on zinc-adequate chow.\ncross_nutrient: false\n[zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149","model_system":"Conditional intestinal knockout with tissue elemental analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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