Component
Mouse heme-regulated eIF2 alpha kinase HRI / Eif2ak1
Mouse heme-regulated eIF2 alpha kinase HRI / Eif2ak1. Species, exposure and limitations are retained in each linked claim.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Iron-deficient Hri-null mice accumulated globin aggregates lacking heme within red cells and their precursors.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/iron-research/11726526.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3", "start_char": 0, "end_char": 1056, "text_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3"}
- experimental_model
- Targeted gene disruption with iron-deficient feeding
- exposure
- Hri deletion crossed with iron deficiency
- limitations
- Combined gene-loss and nutritional stress; the unusual knockout anemia pattern is not the standard description of ordinary iron deficiency.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Mice
- plain_language
- Without the protective brake, cells kept making protein they could not safely assemble.
- primary_references
- [iron-p11726526] Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. (2001). https://pubmed.ncbi.nlm.nih.gov/11726526/ DOI: 10.1093/emboj/20.23.6909
- tissue_or_cell_type
- Erythroid precursors and red cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1122–1133
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted gene disruption with iron-deficient feeding · source_derived_draft · unverified_draft
### iron-hri-globin-aggregation Iron-deficient Hri-null mice accumulated globin aggregates lacking heme within red cells and their precursors. Condition category: machinery_impairment nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Without the protective brake, cells kept making protein they could not safely assemble. organism: Mice tissue_or_cell_type: Erythroid precursors and red cells experimental_model: Targeted gene disruption with iron-deficient feeding limitations: Combined gene-loss and nutritional stress; the unusual knockout anemia pattern is not the standard description of ordinary iron deficiency. exposure: Hri deletion crossed with iron deficiency evidence_span: {"source_cache": "artifacts/iron-research/11726526.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3", "start_char": 0, "end_char": 1056, "text_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3"} [iron-p11726526] Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. (2001). https://pubmed.ncbi.nlm.nih.gov/11726526/ DOI: 10.1093/emboj/20.23.6909
Complete structured claim and evidenceHri-null mice under iron deficiency had accelerated erythroid apoptosis and reduced red-cell counts.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/iron-research/11726526.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3", "start_char": 0, "end_char": 1056, "text_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3"}
- experimental_model
- Targeted gene disruption with iron-deficient feeding
- exposure
- Hri deletion crossed with iron deficiency
- limitations
- Combined gene-loss and nutritional stress; the unusual knockout anemia pattern is not the standard description of ordinary iron deficiency.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Mice
- plain_language
- The failed adaptation damaged the cells meant to carry oxygen.
- primary_references
- [iron-p11726526] Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. (2001). https://pubmed.ncbi.nlm.nih.gov/11726526/ DOI: 10.1093/emboj/20.23.6909
- tissue_or_cell_type
- Erythroid precursors and red cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1135–1146
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted gene disruption with iron-deficient feeding · source_derived_draft · unverified_draft
### iron-hri-survival Hri-null mice under iron deficiency had accelerated erythroid apoptosis and reduced red-cell counts. Condition category: machinery_impairment nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The failed adaptation damaged the cells meant to carry oxygen. organism: Mice tissue_or_cell_type: Erythroid precursors and red cells experimental_model: Targeted gene disruption with iron-deficient feeding limitations: Combined gene-loss and nutritional stress; the unusual knockout anemia pattern is not the standard description of ordinary iron deficiency. exposure: Hri deletion crossed with iron deficiency evidence_span: {"source_cache": "artifacts/iron-research/11726526.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3", "start_char": 0, "end_char": 1056, "text_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3"} [iron-p11726526] Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. (2001). https://pubmed.ncbi.nlm.nih.gov/11726526/ DOI: 10.1093/emboj/20.23.6909
Complete structured claim and evidenceWhen intracellular heme declined, HRI inhibited translation initiation and restrained both alpha- and beta-globin synthesis in erythroid precursors.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/iron-research/11726526.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3", "start_char": 0, "end_char": 1056, "text_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3"}
- experimental_model
- Targeted gene disruption with iron-deficient feeding
- exposure
- Hri deletion crossed with iron deficiency
- limitations
- Combined gene-loss and nutritional stress; the unusual knockout anemia pattern is not the standard description of ordinary iron deficiency.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Mice
- plain_language
- Cells normally slow globin production when there is not enough heme to assemble hemoglobin.
- primary_references
- [iron-p11726526] Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. (2001). https://pubmed.ncbi.nlm.nih.gov/11726526/ DOI: 10.1093/emboj/20.23.6909
- tissue_or_cell_type
- Erythroid precursors and red cells
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1109–1120
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Targeted gene disruption with iron-deficient feeding · source_derived_draft · unverified_draft
### iron-hri-translation When intracellular heme declined, HRI inhibited translation initiation and restrained both alpha- and beta-globin synthesis in erythroid precursors. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Cells normally slow globin production when there is not enough heme to assemble hemoglobin. organism: Mice tissue_or_cell_type: Erythroid precursors and red cells experimental_model: Targeted gene disruption with iron-deficient feeding limitations: Combined gene-loss and nutritional stress; the unusual knockout anemia pattern is not the standard description of ordinary iron deficiency. exposure: Hri deletion crossed with iron deficiency evidence_span: {"source_cache": "artifacts/iron-research/11726526.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3", "start_char": 0, "end_char": 1056, "text_sha256": "6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3"} [iron-p11726526] Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. (2001). https://pubmed.ncbi.nlm.nih.gov/11726526/ DOI: 10.1093/emboj/20.23.6909
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.