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(2001). https://pubmed.ncbi.nlm.nih.gov/11726526/ DOI: 10.1093/emboj/20.23.6909","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Erythroid precursors and red cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9aa6f2e7-7390-5274-988a-4152b5422f68","evidence_kind":"source_excerpt","locator":"Lines 1109-1120","start_line":1109,"end_line":1120,"excerpt":"### iron-hri-translation\nWhen intracellular heme declined, HRI inhibited translation initiation and restrained both alpha- and beta-globin synthesis in erythroid precursors.\nCondition category: normal\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Cells normally slow globin production when there is not enough heme to assemble hemoglobin.\norganism: Mice\ntissue_or_cell_type: Erythroid precursors and red cells\nexperimental_model: Targeted gene disruption with iron-deficient feeding\nlimitations: Combined gene-loss and nutritional stress; the unusual knockout anemia pattern is not the standard description of ordinary iron deficiency.\nexposure: Hri deletion crossed with iron deficiency\nevidence_span: {\"source_cache\": \"artifacts/iron-research/11726526.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3\", \"start_char\": 0, \"end_char\": 1056, \"text_sha256\": \"6182d43925454a0208a74bed0b7da46736b9ff456509b215aa87e3051fe92eb3\"}\n[iron-p11726526] Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. 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