Component
Mouse E2F transcription factor 1 / E2f1
Mouse E2F transcription factor 1 / E2f1. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
E2F1 induction was linked to faster cell-cycle progression during liver regeneration.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chlorogenic_acid-research/41862684.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644", "start_char": 0, "end_char": 1292, "text_sha256": "7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644"}
- experimental_model
- Mouse hepatectomy, genetic tests and Keap1-binding investigation
- exposure
- CGA treatment; doses not provided in indexed abstract
- limitations
- Surgical mouse regeneration is not chronic human fatty-liver treatment. Arg415 binding was reported but the abstract does not identify the species of every recombinant construct; no human KEAP1 residue-specific edge is inferred.
- nutrient_topic
- Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
- organism
- Mus musculus; binding preparation species not resolved from abstract
- plain_language
- The proposed downstream function is recorded separately from gene expression.
- primary_references
- [chlorogenic_acid-p41862684] Chlorogenic acid promotes liver regeneration after partial hepatectomy through activating Nrf2 via directly targeting Keap1. (2026). https://pubmed.ncbi.nlm.nih.gov/41862684/ DOI: 10.1038/s41401-026-01770-4
- tissue_or_cell_type
- Regenerating liver after 70% or 90% partial hepatectomy
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 568–579
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse hepatectomy, genetic tests and Keap1-binding investigation · source_derived_draft · unverified_draft
### chlorogenic_acid-e2f1-cycle E2F1 induction was linked to faster cell-cycle progression during liver regeneration. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The proposed downstream function is recorded separately from gene expression. organism: Mus musculus; binding preparation species not resolved from abstract tissue_or_cell_type: Regenerating liver after 70% or 90% partial hepatectomy experimental_model: Mouse hepatectomy, genetic tests and Keap1-binding investigation limitations: Surgical mouse regeneration is not chronic human fatty-liver treatment. Arg415 binding was reported but the abstract does not identify the species of every recombinant construct; no human KEAP1 residue-specific edge is inferred. exposure: CGA treatment; doses not provided in indexed abstract evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/41862684.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644", "start_char": 0, "end_char": 1292, "text_sha256": "7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644"} [chlorogenic_acid-p41862684] Chlorogenic acid promotes liver regeneration after partial hepatectomy through activating Nrf2 via directly targeting Keap1. (2026). https://pubmed.ncbi.nlm.nih.gov/41862684/ DOI: 10.1038/s41401-026-01770-4
Complete structured claim and evidence
What acts on it
Nrf2 activation increased E2F1 mRNA in the regeneration model.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chlorogenic_acid-research/41862684.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644", "start_char": 0, "end_char": 1292, "text_sha256": "7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644"}
- experimental_model
- Mouse hepatectomy, genetic tests and Keap1-binding investigation
- exposure
- CGA treatment; doses not provided in indexed abstract
- limitations
- Surgical mouse regeneration is not chronic human fatty-liver treatment. Arg415 binding was reported but the abstract does not identify the species of every recombinant construct; no human KEAP1 residue-specific edge is inferred.
- nutrient_topic
- Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
- organism
- Mus musculus; binding preparation species not resolved from abstract
- plain_language
- The response connects to machinery controlling cell division.
- primary_references
- [chlorogenic_acid-p41862684] Chlorogenic acid promotes liver regeneration after partial hepatectomy through activating Nrf2 via directly targeting Keap1. (2026). https://pubmed.ncbi.nlm.nih.gov/41862684/ DOI: 10.1038/s41401-026-01770-4
- tissue_or_cell_type
- Regenerating liver after 70% or 90% partial hepatectomy
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 555–566
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse hepatectomy, genetic tests and Keap1-binding investigation · source_derived_draft · unverified_draft
### chlorogenic_acid-nrf2-e2f1 Nrf2 activation increased E2F1 mRNA in the regeneration model. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The response connects to machinery controlling cell division. organism: Mus musculus; binding preparation species not resolved from abstract tissue_or_cell_type: Regenerating liver after 70% or 90% partial hepatectomy experimental_model: Mouse hepatectomy, genetic tests and Keap1-binding investigation limitations: Surgical mouse regeneration is not chronic human fatty-liver treatment. Arg415 binding was reported but the abstract does not identify the species of every recombinant construct; no human KEAP1 residue-specific edge is inferred. exposure: CGA treatment; doses not provided in indexed abstract evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/41862684.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644", "start_char": 0, "end_char": 1292, "text_sha256": "7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644"} [chlorogenic_acid-p41862684] Chlorogenic acid promotes liver regeneration after partial hepatectomy through activating Nrf2 via directly targeting Keap1. (2026). https://pubmed.ncbi.nlm.nih.gov/41862684/ DOI: 10.1038/s41401-026-01770-4
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.