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(2026). https://pubmed.ncbi.nlm.nih.gov/41862684/ DOI: 10.1038/s41401-026-01770-4","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Regenerating liver after 70% or 90% partial hepatectomy","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c1d5c275-8ab7-561f-8914-c7058d870e0e","evidence_kind":"source_excerpt","locator":"Lines 568-579","start_line":568,"end_line":579,"excerpt":"### chlorogenic_acid-e2f1-cycle\nE2F1 induction was linked to faster cell-cycle progression during liver regeneration.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The proposed downstream function is recorded separately from gene expression.\norganism: Mus musculus; binding preparation species not resolved from abstract\ntissue_or_cell_type: Regenerating liver after 70% or 90% partial hepatectomy\nexperimental_model: Mouse hepatectomy, genetic tests and Keap1-binding investigation\nlimitations: Surgical mouse regeneration is not chronic human fatty-liver treatment. Arg415 binding was reported but the abstract does not identify the species of every recombinant construct; no human KEAP1 residue-specific edge is inferred.\nexposure: CGA treatment; doses not provided in indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/41862684.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644\", \"start_char\": 0, \"end_char\": 1292, \"text_sha256\": \"7246caa586cbd35b79fa9518b522dc7c1d330aad71c98611ae7cc763f7952644\"}\n[chlorogenic_acid-p41862684] Chlorogenic acid promotes liver regeneration after partial hepatectomy through activating Nrf2 via directly targeting Keap1. 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