Component
Mouse DSS colitis severity
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Colon-specific Pparg deletion abolished the protective effect of dietary CLA against DSS colitis.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Conditional mouse deletion and matched littermate feeding study.
- limitations
- Mixture-specific animal result, not a human inflammatory-bowel-disease treatment.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- Removing the regulator removed protection in this model.
- primary_references
- Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15362034/ · DOI 10.1053/j.gastro.2004.06.049
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 366–372
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Conditional mouse deletion and matched littermate feeding study. · source_derived_draft · unverified_draft
## cla-colitis-deletion Removing the regulator removed protection in this model. Colon-specific Pparg deletion abolished the protective effect of dietary CLA against DSS colitis. Model: Conditional mouse deletion and matched littermate feeding study. Limitations: Mixture-specific animal result, not a human inflammatory-bowel-disease treatment. Evidence access: Primary abstract Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15362034/ · DOI 10.1053/j.gastro.2004.06.049
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.