{"id":"fa9188fa-1f65-5010-9e6c-54b5b228f4cc","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-colitis-deletion","predicate":"deletion_abrogates","statement":"Colon-specific Pparg deletion abolished the protective effect of dietary CLA against DSS colitis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"44a137f2-5971-57bb-94b1-e7c0b3accbdf","mechanism_event_label":"Removing the regulator removed protection in this model.","subject":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"object":{"id":"2ecf05b6-3524-5317-b996-f8e738bd1cee","slug":"mouse-dss-colitis-severity","display_name":"Mouse DSS colitis severity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"44a137f2-5971-57bb-94b1-e7c0b3accbdf","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-colitis-deletion-event","event_type":"observed_relationship","label":"Removing the regulator removed protection in this model.","description":"Colon-specific Pparg deletion abolished the protective effect of dietary CLA against DSS colitis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2ecf05b6-3524-5317-b996-f8e738bd1cee","slug":"mouse-dss-colitis-severity","display_name":"Mouse DSS colitis severity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Conditional mouse deletion and matched littermate feeding study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mixture-specific animal result, not a human inflammatory-bowel-disease treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Removing the regulator removed protection in this model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15362034/ · DOI 10.1053/j.gastro.2004.06.049","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c8c8f9ce-0eeb-5d9d-ba8b-f5e13b138cc2","evidence_kind":"source_excerpt","locator":"Lines 366-372","start_line":366,"end_line":372,"excerpt":"## cla-colitis-deletion\nRemoving the regulator removed protection in this model.\nColon-specific Pparg deletion abolished the protective effect of dietary CLA against DSS colitis.\nModel: Conditional mouse deletion and matched littermate feeding study.\nLimitations: Mixture-specific animal result, not a human inflammatory-bowel-disease treatment.\nEvidence access: Primary abstract\nActivation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15362034/ · DOI 10.1053/j.gastro.2004.06.049","model_system":"Conditional mouse deletion and matched littermate feeding study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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