Component
Mouse ClC-7 chloride/proton exchanger / Clcn7
Mouse ClC-7 chloride/proton exchanger / Clcn7. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Clcn7-null osteoclasts failed to acidify the resorption lacuna.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/chloride-research/11207362.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5e10ae61257fa402ab9e10d55af44013139462a9d85236b75f5b52bdea0c7b5a", "start_char": 0, "end_char": 821, "text_sha256": "5e10ae61257fa402ab9e10d55af44013139462a9d85236b75f5b52bdea0c7b5a"}
- experimental_model
- Clcn7 knockout and human mutation identification
- exposure
- ClC-7 loss
- limitations
- Historical title calls ClC-7 a channel; current exchanger classification does not change the reported knockout phenotype. Not a dietary chloride study.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Mouse; human infantile osteopetrosis patient
- plain_language
- Chloride-handling machinery supports the acidic compartment used to resorb bone.
- primary_references
- [chloride-p11207362] Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. (2001). https://pubmed.ncbi.nlm.nih.gov/11207362/ DOI: 10.1016/s0092-8674(01)00206-9
- tissue_or_cell_type
- Osteoclast ruffled border
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 770–781
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Clcn7 knockout and human mutation identification · source_derived_draft · unverified_draft
### chloride-clc7-acidification Clcn7-null osteoclasts failed to acidify the resorption lacuna. Condition category: machinery_impairment nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: Chloride-handling machinery supports the acidic compartment used to resorb bone. organism: Mouse; human infantile osteopetrosis patient tissue_or_cell_type: Osteoclast ruffled border experimental_model: Clcn7 knockout and human mutation identification limitations: Historical title calls ClC-7 a channel; current exchanger classification does not change the reported knockout phenotype. Not a dietary chloride study. exposure: ClC-7 loss evidence_span: {"source_cache": "artifacts/chloride-research/11207362.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5e10ae61257fa402ab9e10d55af44013139462a9d85236b75f5b52bdea0c7b5a", "start_char": 0, "end_char": 821, "text_sha256": "5e10ae61257fa402ab9e10d55af44013139462a9d85236b75f5b52bdea0c7b5a"} [chloride-p11207362] Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. (2001). https://pubmed.ncbi.nlm.nih.gov/11207362/ DOI: 10.1016/s0092-8674(01)00206-9
Complete structured claim and evidenceClcn7-null mice had severe osteopetrosis despite normal osteoclast numbers.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/chloride-research/11207362.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5e10ae61257fa402ab9e10d55af44013139462a9d85236b75f5b52bdea0c7b5a", "start_char": 0, "end_char": 821, "text_sha256": "5e10ae61257fa402ab9e10d55af44013139462a9d85236b75f5b52bdea0c7b5a"}
- experimental_model
- Clcn7 knockout and human mutation identification
- exposure
- ClC-7 loss
- limitations
- Historical title calls ClC-7 a channel; current exchanger classification does not change the reported knockout phenotype. Not a dietary chloride study.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Mouse; human infantile osteopetrosis patient
- plain_language
- Having bone-resorbing cells is insufficient when their transport machinery fails.
- primary_references
- [chloride-p11207362] Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. (2001). https://pubmed.ncbi.nlm.nih.gov/11207362/ DOI: 10.1016/s0092-8674(01)00206-9
- tissue_or_cell_type
- Osteoclast ruffled border
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 783–794
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Clcn7 knockout and human mutation identification · source_derived_draft · unverified_draft
### chloride-clc7-bone Clcn7-null mice had severe osteopetrosis despite normal osteoclast numbers. Condition category: machinery_impairment nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: Having bone-resorbing cells is insufficient when their transport machinery fails. organism: Mouse; human infantile osteopetrosis patient tissue_or_cell_type: Osteoclast ruffled border experimental_model: Clcn7 knockout and human mutation identification limitations: Historical title calls ClC-7 a channel; current exchanger classification does not change the reported knockout phenotype. Not a dietary chloride study. exposure: ClC-7 loss evidence_span: {"source_cache": "artifacts/chloride-research/11207362.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5e10ae61257fa402ab9e10d55af44013139462a9d85236b75f5b52bdea0c7b5a", "start_char": 0, "end_char": 821, "text_sha256": "5e10ae61257fa402ab9e10d55af44013139462a9d85236b75f5b52bdea0c7b5a"} [chloride-p11207362] Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. (2001). https://pubmed.ncbi.nlm.nih.gov/11207362/ DOI: 10.1016/s0092-8674(01)00206-9
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.