Component
Mouse CD36 movement to the cell surface
Mouse CD36 movement to the cell surface. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Chromium picolinate increased plasma-membrane CD36 localization in 3T3-L1 adipocytes; combining it with insulin did not produce additive CD36 translocation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chromium-research/20721637.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "550ce1e2898494fb6f385c11a446c6516812bffacefc4c78161fbee16adfc39f", "start_char": 0, "end_char": 1671, "text_sha256": "550ce1e2898494fb6f385c11a446c6516812bffacefc4c78161fbee16adfc39f"}
- experimental_model
- Transporter localization and substrate-uptake assays
- exposure
- Insulin, chromium picolinate and wortmannin comparisons
- limitations
- Membrane localization is not equivalent to transporter activity. CD36 trafficking responses to insulin and chromium were not additive; results do not show a general increase in beneficial fatty-acid disposal.
- nutrient_topic
- Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
- organism
- Mouse 3T3-L1 adipocytes
- plain_language
- Chromium affected a fatty-acid transporter as well as GLUT4, with a different response pattern.
- primary_references
- [chromium-p20721637] Insulin and chromium picolinate induce translocation of CD36 to the plasma membrane through different signaling pathways in 3T3-L1 adipocytes, and with a differential functionality of the CD36. (2011). https://pubmed.ncbi.nlm.nih.gov/20721637/ DOI: 10.1007/s12011-010-8809-8
- tissue_or_cell_type
- Plasma membrane
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 458–469
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter localization and substrate-uptake assays · source_derived_draft · unverified_draft
### chromium-cd36-trafficking Chromium picolinate increased plasma-membrane CD36 localization in 3T3-L1 adipocytes; combining it with insulin did not produce additive CD36 translocation. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Chromium affected a fatty-acid transporter as well as GLUT4, with a different response pattern. organism: Mouse 3T3-L1 adipocytes tissue_or_cell_type: Plasma membrane experimental_model: Transporter localization and substrate-uptake assays limitations: Membrane localization is not equivalent to transporter activity. CD36 trafficking responses to insulin and chromium were not additive; results do not show a general increase in beneficial fatty-acid disposal. exposure: Insulin, chromium picolinate and wortmannin comparisons evidence_span: {"source_cache": "artifacts/chromium-research/20721637.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "550ce1e2898494fb6f385c11a446c6516812bffacefc4c78161fbee16adfc39f", "start_char": 0, "end_char": 1671, "text_sha256": "550ce1e2898494fb6f385c11a446c6516812bffacefc4c78161fbee16adfc39f"} [chromium-p20721637] Insulin and chromium picolinate induce translocation of CD36 to the plasma membrane through different signaling pathways in 3T3-L1 adipocytes, and with a differential functionality of the CD36. (2011). https://pubmed.ncbi.nlm.nih.gov/20721637/ DOI: 10.1007/s12011-010-8809-8
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.