Component
Mouse pancreatic beta-cell membrane depolarization
Study-scoped entity; inspect species, exposure and experimental limitations on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
The calcium response required depolarization and extracellular calcium.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse pancreatic beta cells; electrophysiology, calcium imaging and secretion experiments.
- limitations
- No direct change in whole-cell calcium or ATP-sensitive potassium currents was detected.
- nutrient_topic
- L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
- plain_language
- The electrical change links arginine transport to calcium entry.
- primary_references
- Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9130159/ · DOI 10.1113/jphysiol.1997.sp021955
L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 310–316
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse pancreatic beta cells; electrophysiology, calcium imaging and secretion experiments. · source_derived_draft · unverified_draft
## arg-beta-calcium The electrical change links arginine transport to calcium entry. The calcium response required depolarization and extracellular calcium. Model: Mouse pancreatic beta cells; electrophysiology, calcium imaging and secretion experiments. Limitations: No direct change in whole-cell calcium or ATP-sensitive potassium currents was detected. Evidence access: Primary abstract Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9130159/ · DOI 10.1113/jphysiol.1997.sp021955
Complete structured claim and evidenceArginine generated an inward current carried by the amino acid; CAT2A-mediated electrogenic uptake was the proposed route.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse pancreatic beta cells; electrophysiology, calcium imaging and secretion experiments.
- limitations
- Cell/animal mechanism; no universal human insulin response inferred. NAD(P)H autofluorescence did not show increased metabolism.
- nutrient_topic
- L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
- plain_language
- Moving a positively charged amino acid can change membrane voltage.
- primary_references
- Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9130159/ · DOI 10.1113/jphysiol.1997.sp021955
L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 302–308
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse pancreatic beta cells; electrophysiology, calcium imaging and secretion experiments. · source_derived_draft · unverified_draft
## arg-beta-current Moving a positively charged amino acid can change membrane voltage. Arginine generated an inward current carried by the amino acid; CAT2A-mediated electrogenic uptake was the proposed route. Model: Mouse pancreatic beta cells; electrophysiology, calcium imaging and secretion experiments. Limitations: Cell/animal mechanism; no universal human insulin response inferred. NAD(P)H autofluorescence did not show increased metabolism. Evidence access: Primary abstract Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells. · 1997 · https://pubmed.ncbi.nlm.nih.gov/9130159/ · DOI 10.1113/jphysiol.1997.sp021955
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.