Component
Mouse beta-carotene oxygenase 1 / Bco1
Mouse beta-carotene oxygenase 1 / Bco1. Species, exposure and limitations are retained in each linked claim.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Bco1-null mice had lower liver lycopene than Bco2-null or double-knockout mice; comparison with wild type was not significant.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/37269907.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756", "start_char": 0, "end_char": 1986, "text_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756"}
- experimental_model
- Carotenoid-enzyme knockout comparison and vitamin-A diet experiment
- exposure
- 1 mg lycopene in cottonseed oil daily for two weeks; separate vitamin-A-deficient versus sufficient diets
- limitations
- Mouse knockout distribution does not directly quantify human cleavage; increased ISX signaling does not prove conversion to vitamin A.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Mouse
- plain_language
- Removing a cleavage enzyme did not produce a simple universal accumulation rule.
- primary_references
- [lycopene-p37269907] Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes. (2023). https://pubmed.ncbi.nlm.nih.gov/37269907/ DOI: 10.1016/j.tjnut.2023.05.025
- tissue_or_cell_type
- Liver, other tissues and intestinal gene expression
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 819–830
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Carotenoid-enzyme knockout comparison and vitamin-A diet experiment · source_derived_draft · unverified_draft
### lycopene-mouse-bco1-loss Bco1-null mice had lower liver lycopene than Bco2-null or double-knockout mice; comparison with wild type was not significant. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing a cleavage enzyme did not produce a simple universal accumulation rule. organism: Mouse tissue_or_cell_type: Liver, other tissues and intestinal gene expression experimental_model: Carotenoid-enzyme knockout comparison and vitamin-A diet experiment limitations: Mouse knockout distribution does not directly quantify human cleavage; increased ISX signaling does not prove conversion to vitamin A. exposure: 1 mg lycopene in cottonseed oil daily for two weeks; separate vitamin-A-deficient versus sufficient diets evidence_span: {"source_cache": "artifacts/lycopene-research/37269907.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756", "start_char": 0, "end_char": 1986, "text_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756"} [lycopene-p37269907] Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes. (2023). https://pubmed.ncbi.nlm.nih.gov/37269907/ DOI: 10.1016/j.tjnut.2023.05.025
Complete structured claim and evidenceLycopene-containing diets increased intestinal ISX expression relative to the vitamin-A-deficient control group.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/37269907.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756", "start_char": 0, "end_char": 1986, "text_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756"}
- experimental_model
- Carotenoid-enzyme knockout comparison and vitamin-A diet experiment
- exposure
- 1 mg lycopene in cottonseed oil daily for two weeks; separate vitamin-A-deficient versus sufficient diets
- limitations
- Mouse knockout distribution does not directly quantify human cleavage; increased ISX signaling does not prove conversion to vitamin A.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Mouse
- plain_language
- Carotenoid exposure intersected a vitamin-A-responsive regulatory system.
- primary_references
- [lycopene-p37269907] Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes. (2023). https://pubmed.ncbi.nlm.nih.gov/37269907/ DOI: 10.1016/j.tjnut.2023.05.025
- tissue_or_cell_type
- Liver, other tissues and intestinal gene expression
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 845–856
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Carotenoid-enzyme knockout comparison and vitamin-A diet experiment · source_derived_draft · unverified_draft
### lycopene-mouse-isx Lycopene-containing diets increased intestinal ISX expression relative to the vitamin-A-deficient control group. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Carotenoid exposure intersected a vitamin-A-responsive regulatory system. organism: Mouse tissue_or_cell_type: Liver, other tissues and intestinal gene expression experimental_model: Carotenoid-enzyme knockout comparison and vitamin-A diet experiment limitations: Mouse knockout distribution does not directly quantify human cleavage; increased ISX signaling does not prove conversion to vitamin A. exposure: 1 mg lycopene in cottonseed oil daily for two weeks; separate vitamin-A-deficient versus sufficient diets evidence_span: {"source_cache": "artifacts/lycopene-research/37269907.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756", "start_char": 0, "end_char": 1986, "text_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756"} [lycopene-p37269907] Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes. (2023). https://pubmed.ncbi.nlm.nih.gov/37269907/ DOI: 10.1016/j.tjnut.2023.05.025
Complete structured claim and evidenceLycopene was enriched three- to fivefold in hepatic mitochondria compared with total hepatic content across the tested genotypes.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/37269907.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756", "start_char": 0, "end_char": 1986, "text_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756"}
- experimental_model
- Carotenoid-enzyme knockout comparison and vitamin-A diet experiment
- exposure
- 1 mg lycopene in cottonseed oil daily for two weeks; separate vitamin-A-deficient versus sufficient diets
- limitations
- Mouse knockout distribution does not directly quantify human cleavage; increased ISX signaling does not prove conversion to vitamin A.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Mouse
- plain_language
- Location inside the cell matters as well as the total amount.
- primary_references
- [lycopene-p37269907] Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes. (2023). https://pubmed.ncbi.nlm.nih.gov/37269907/ DOI: 10.1016/j.tjnut.2023.05.025
- tissue_or_cell_type
- Liver, other tissues and intestinal gene expression
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 832–843
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Carotenoid-enzyme knockout comparison and vitamin-A diet experiment · source_derived_draft · unverified_draft
### lycopene-mouse-mitochondria Lycopene was enriched three- to fivefold in hepatic mitochondria compared with total hepatic content across the tested genotypes. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Location inside the cell matters as well as the total amount. organism: Mouse tissue_or_cell_type: Liver, other tissues and intestinal gene expression experimental_model: Carotenoid-enzyme knockout comparison and vitamin-A diet experiment limitations: Mouse knockout distribution does not directly quantify human cleavage; increased ISX signaling does not prove conversion to vitamin A. exposure: 1 mg lycopene in cottonseed oil daily for two weeks; separate vitamin-A-deficient versus sufficient diets evidence_span: {"source_cache": "artifacts/lycopene-research/37269907.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756", "start_char": 0, "end_char": 1986, "text_sha256": "36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756"} [lycopene-p37269907] Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes. (2023). https://pubmed.ncbi.nlm.nih.gov/37269907/ DOI: 10.1016/j.tjnut.2023.05.025
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.