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(2023). https://pubmed.ncbi.nlm.nih.gov/37269907/ DOI: 10.1016/j.tjnut.2023.05.025","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver, other tissues and intestinal gene expression","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"995ea7ae-5d13-5d7d-a099-238c08f89214","evidence_kind":"source_excerpt","locator":"Lines 819-830","start_line":819,"end_line":830,"excerpt":"### lycopene-mouse-bco1-loss\nBco1-null mice had lower liver lycopene than Bco2-null or double-knockout mice; comparison with wild type was not significant.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Removing a cleavage enzyme did not produce a simple universal accumulation rule.\norganism: Mouse\ntissue_or_cell_type: Liver, other tissues and intestinal gene expression\nexperimental_model: Carotenoid-enzyme knockout comparison and vitamin-A diet experiment\nlimitations: Mouse knockout distribution does not directly quantify human cleavage; increased ISX signaling does not prove conversion to vitamin A.\nexposure: 1 mg lycopene in cottonseed oil daily for two weeks; separate vitamin-A-deficient versus sufficient diets\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/37269907.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756\", \"start_char\": 0, \"end_char\": 1986, \"text_sha256\": \"36b39754d4d3b4ed8721a15f8dffe03bfd387dcbef3ff50918daabb45c48e756\"}\n[lycopene-p37269907] Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes. 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