Component
Mouse cognitive/synaptic response during antipsychotic exposure
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Hippocampal neuronal-specific PTP1B deletion prevented olanzapine-induced synaptic and cognitive deficits in mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Cell-type-specific mouse genetic intervention.
- limitations
- Does not mean ergothioneine reproduces every consequence of genetic deletion.
- nutrient_topic
- Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
- plain_language
- Removing the proposed target tested its role in the injury pathway.
- primary_references
- Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42013837/ · DOI 10.1016/j.chom.2026.03.020
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 448–454
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Cell-type-specific mouse genetic intervention. · source_derived_draft · unverified_draft
## ergothioneine-mouse-ptp1b-deletion Removing the proposed target tested its role in the injury pathway. Hippocampal neuronal-specific PTP1B deletion prevented olanzapine-induced synaptic and cognitive deficits in mice. Model: Cell-type-specific mouse genetic intervention. Limitations: Does not mean ergothioneine reproduces every consequence of genetic deletion. Evidence access: Primary abstract Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42013837/ · DOI 10.1016/j.chom.2026.03.020
Complete structured claim and evidence
Where it participates (unsigned role)
Ergothioneine supplementation inhibited hippocampal PTP1B-associated signaling and mitigated synaptic/cognitive impairment in olanzapine-treated mice.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse gut-brain study with supplementation.
- limitations
- Abstract supports inhibition but does not establish a direct binding site or human efficacy.
- nutrient_topic
- Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
- plain_language
- A phosphatase links the compound to a brain signaling pathway.
- primary_references
- Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42013837/ · DOI 10.1016/j.chom.2026.03.020
Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 440–446
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse gut-brain study with supplementation. · source_derived_draft · unverified_draft
## ergothioneine-mouse-ptp1b-inhibition A phosphatase links the compound to a brain signaling pathway. Ergothioneine supplementation inhibited hippocampal PTP1B-associated signaling and mitigated synaptic/cognitive impairment in olanzapine-treated mice. Model: Mouse gut-brain study with supplementation. Limitations: Abstract supports inhibition but does not establish a direct binding site or human efficacy. Evidence access: Primary abstract Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42013837/ · DOI 10.1016/j.chom.2026.03.020
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.