{"id":"654f982d-a3ba-53fa-83e1-bd45174529b4","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-mouse-ptp1b-inhibition","predicate":"inhibits","statement":"Ergothioneine supplementation inhibited hippocampal PTP1B-associated signaling and mitigated synaptic/cognitive impairment in olanzapine-treated mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"057699f1-2c16-5070-a9ad-5d6932acfd6d","mechanism_event_label":"A phosphatase links the compound to a brain signaling pathway.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"b4560a70-6c3c-5df1-a9ae-33eabd4761ec","slug":"mouse-ptpn1","display_name":"Mouse protein tyrosine phosphatase 1B / Ptpn1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"057699f1-2c16-5070-a9ad-5d6932acfd6d","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-mouse-ptp1b-inhibition-event","event_type":"observed_relationship","label":"A phosphatase links the compound to a brain signaling pathway.","description":"Ergothioneine supplementation inhibited hippocampal PTP1B-associated signaling and mitigated synaptic/cognitive impairment in olanzapine-treated mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b4560a70-6c3c-5df1-a9ae-33eabd4761ec","slug":"mouse-ptpn1","display_name":"Mouse protein tyrosine phosphatase 1B / Ptpn1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e614d7fd-f054-5b8c-a13b-077829cb73c4","slug":"mouse-antipsychotic-cognitive-response","display_name":"Mouse cognitive/synaptic response during antipsychotic exposure","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse gut-brain study with supplementation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Abstract supports inhibition but does not establish a direct binding site or human efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A phosphatase links the compound to a brain signaling pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42013837/ · DOI 10.1016/j.chom.2026.03.020","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"18011518-8f5b-5441-9102-745647d80284","evidence_kind":"source_excerpt","locator":"Lines 440-446","start_line":440,"end_line":446,"excerpt":"## ergothioneine-mouse-ptp1b-inhibition\nA phosphatase links the compound to a brain signaling pathway.\nErgothioneine supplementation inhibited hippocampal PTP1B-associated signaling and mitigated synaptic/cognitive impairment in olanzapine-treated mice.\nModel: Mouse gut-brain study with supplementation.\nLimitations: Abstract supports inhibition but does not establish a direct binding site or human efficacy.\nEvidence access: Primary abstract\nGut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42013837/ · DOI 10.1016/j.chom.2026.03.020","model_system":"Mouse gut-brain study with supplementation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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