Component

Silica uptake in mouse alveolar macrophages

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. MARCO loss or antibody blockade prevented silica uptake and cytotoxicity in C57BL/6 alveolar macrophages.

    Mouse MARCO → Silica uptake in mouse alveolar macrophages source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Primary mouse macrophages; receptor-null and antibody experiments.
    limitations
    Mouse strain matters: BALB/c uptake was not blocked by the same receptor antibodies.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A scavenger receptor can gate particle entry.
    primary_references
    MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16984918/ · DOI 10.1074/jbc.M605229200
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 408–414

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary mouse macrophages; receptor-null and antibody experiments. · source_derived_draft · unverified_draft

    ## silica-marco-uptake A scavenger receptor can gate particle entry. MARCO loss or antibody blockade prevented silica uptake and cytotoxicity in C57BL/6 alveolar macrophages. Model: Primary mouse macrophages; receptor-null and antibody experiments. Limitations: Mouse strain matters: BALB/c uptake was not blocked by the same receptor antibodies. Evidence access: Primary abstract MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16984918/ · DOI 10.1074/jbc.M605229200
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Cytochalasin D blocked silica uptake and IL-1 beta release, supporting a phagocytosis-dependent interpretation.

    Cytochalasin-D uptake blockade in the 2008 silica study → Mouse IL-1 beta source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse macrophages; related human PBMC result separately reported in the paper.
    limitations
    Inhibitor dose and non-uptake effects require comparison with later low-dose experiments. Correction record: A 2026 author correction replaces an erroneously duplicated lower-left Fig. 8c micrograph with the retrieved original. This is a figure correction, not a scientific contradiction or retraction. https://www.nature.com/articles/s41590-026-02468-9
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Blocking engulfment also blocked inflammatory output in this experiment.
    primary_references
    Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18604214/ · DOI 10.1038/ni.1631
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 432–438

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse macrophages; related human PBMC result separately reported in the paper. · source_derived_draft · unverified_draft

    ## silica-uptake-block-2008 Blocking engulfment also blocked inflammatory output in this experiment. Cytochalasin D blocked silica uptake and IL-1 beta release, supporting a phagocytosis-dependent interpretation. Model: Mouse macrophages; related human PBMC result separately reported in the paper. Limitations: Inhibitor dose and non-uptake effects require comparison with later low-dose experiments. Correction record: A 2026 author correction replaces an erroneously duplicated lower-left Fig. 8c micrograph with the retrieved original. This is a figure correction, not a scientific contradiction or retraction. https://www.nature.com/articles/s41590-026-02468-9 Evidence access: Primary full text Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18604214/ · DOI 10.1038/ni.1631
    Complete structured claim and evidence

  2. Low-dose cytochalasin D blocked silica engulfment while preserving caspase-1 processing and IL-1 beta release.

    Low-dose cytochalasin D in the 2014 silica study → Mouse IL-1 beta source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Mouse bone-marrow macrophages; 0.25–0.5 micromolar cytochalasin D.
    limitations
    Immobilized epoxy-crystal experiments used MSU, not silica; do not transfer that detail between materials.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Surface-associated crystals could still trigger a response when uptake was blocked.
    primary_references
    Activation of NLRP3 inflammasome by crystalline structures via cell surface contact. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25445147/ · DOI 10.1038/srep07281

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 464–470

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse bone-marrow macrophages; 0.25–0.5 micromolar cytochalasin D. · source_derived_draft · unverified_draft

    ## silica-uptake-block-2014 Surface-associated crystals could still trigger a response when uptake was blocked. Low-dose cytochalasin D blocked silica engulfment while preserving caspase-1 processing and IL-1 beta release. Model: Mouse bone-marrow macrophages; 0.25–0.5 micromolar cytochalasin D. Limitations: Immobilized epoxy-crystal experiments used MSU, not silica; do not transfer that detail between materials. Evidence access: Primary full text Activation of NLRP3 inflammasome by crystalline structures via cell surface contact. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25445147/ · DOI 10.1038/srep07281
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards