{"id":"e52b49b9-7fce-55da-8353-bf3d2cf9fa37","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-marco-uptake","predicate":"supports","statement":"MARCO loss or antibody blockade prevented silica uptake and cytotoxicity in C57BL/6 alveolar macrophages.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0d50a305-80e0-5e1c-9cf4-1a9a15658059","mechanism_event_label":"A scavenger receptor can gate particle entry.","subject":{"id":"6aa0ad36-6549-5c4a-9b2b-61ccd7ad446a","slug":"mouse-marco","display_name":"Mouse MARCO","entity_type_key":"protein"},"object":{"id":"5165cee3-71fa-5248-ab5d-fefded3492c5","slug":"mouse-alveolar-silica-uptake","display_name":"Silica uptake in mouse alveolar macrophages","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0d50a305-80e0-5e1c-9cf4-1a9a15658059","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-marco-uptake-event","event_type":"observed_relationship","label":"A scavenger receptor can gate particle entry.","description":"MARCO loss or antibody blockade prevented silica uptake and cytotoxicity in C57BL/6 alveolar macrophages.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6aa0ad36-6549-5c4a-9b2b-61ccd7ad446a","slug":"mouse-marco","display_name":"Mouse MARCO","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5165cee3-71fa-5248-ab5d-fefded3492c5","slug":"mouse-alveolar-silica-uptake","display_name":"Silica uptake in mouse alveolar macrophages","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b2d4231b-3893-5d4e-8b52-d0effdaa26c9","slug":"crystalline-silica","display_name":"Crystalline silica / quartz particles","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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