Component
Aqueous and methanolic Moringa leaf extracts
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Moringa methanolic and aqueous leaf extracts inhibited CYP3A4-mediated testosterone 6-beta-hydroxylation in mixed-sex human liver microsomes, with reported IC50 values of 0.5 and 2.5 mg/mL.
Experimental context and source evidence
- dose
- Leaf extracts from 0.01 to 10 mg/mL
- duration
- Incubation interval specified in the primary article
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Mixed-sex human liver microsomes
- limitations
- Extract concentrations and microsomal inhibition do not predict a clinical interaction without constituent exposure and intestinal/hepatic concentrations.
- nutrient_topic
- Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Moringa oleifera
- organism
- Mixed-sex human liver microsomes
- plain_language
- Moringa methanolic and aqueous leaf extracts inhibited CYP3A4-mediated testosterone 6-beta-hydroxylation in mixed-sex human liver microsomes, with reported IC50 values of 0.5 and 2.5 mg/mL.
- primary_references
- Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. (2008). https://pubmed.ncbi.nlm.nih.gov/19745507/ DOI: 10.3855/jidc.201
- route
- In vitro
- tissue
- CYP3A4 testosterone 6-beta-hydroxylation
Moringa oleifera: mechanism of action and interactions (2026-09-20) · lines 200–209
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Mixed-sex human liver microsomes · source_derived_draft · unverified_draft
## moringa-leaf-extract-cyp3a4 Moringa methanolic and aqueous leaf extracts inhibited CYP3A4-mediated testosterone 6-beta-hydroxylation in mixed-sex human liver microsomes, with reported IC50 values of 0.5 and 2.5 mg/mL. Model/species: Mixed-sex human liver microsomes Tissue/system: CYP3A4 testosterone 6-beta-hydroxylation Exposure: Leaf extracts from 0.01 to 10 mg/mL Route: In vitro Duration: Incubation interval specified in the primary article Limits: Extract concentrations and microsomal inhibition do not predict a clinical interaction without constituent exposure and intestinal/hepatic concentrations. Primary reference: Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. (2008). https://pubmed.ncbi.nlm.nih.gov/19745507/ DOI: 10.3855/jidc.201 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.