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(2008). https://pubmed.ncbi.nlm.nih.gov/19745507/ DOI: 10.3855/jidc.201","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"CYP3A4 testosterone 6-beta-hydroxylation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e41f7c57-b64b-5001-94c2-0cd098891a06","evidence_kind":"source_excerpt","locator":"Lines 200-209","start_line":200,"end_line":209,"excerpt":"## moringa-leaf-extract-cyp3a4\nMoringa methanolic and aqueous leaf extracts inhibited CYP3A4-mediated testosterone 6-beta-hydroxylation in mixed-sex human liver microsomes, with reported IC50 values of 0.5 and 2.5 mg/mL.\nModel/species: Mixed-sex human liver microsomes\nTissue/system: CYP3A4 testosterone 6-beta-hydroxylation\nExposure: Leaf extracts from 0.01 to 10 mg/mL\nRoute: In vitro\nDuration: Incubation interval specified in the primary article\nLimits: Extract concentrations and microsomal inhibition do not predict a clinical interaction without constituent exposure and intestinal/hepatic concentrations.\nPrimary reference: Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. (2008). https://pubmed.ncbi.nlm.nih.gov/19745507/ DOI: 10.3855/jidc.201\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Mixed-sex human liver microsomes","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2752e9b3-e4b9-55fe-be07-944204cca4b8","stable_key":"import-16c35a72-8162-5bb1-ae01-45331b8b42d0","title":"Moringa oleifera: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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