Component

Monkey COS-7-cell inositol monophosphatase activity

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Lithium increased autophagy markers through an IMPase-linked route without the mTOR inhibition detected with rapamycin.

    Lithium ion (Li+) → Monkey COS-7-cell lithium-associated autophagy source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Monkey COS-7; 10 mM LiCl, LC3 and pathway assays.
    limitations
    Not evidence that every lithium exposure increases completed autophagic flux or human longevity.
    nutrient_topic
    Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Lithium
    plain_language
    Cellular recycling can change through a route outside mTOR.
    primary_references
    Lithium induces autophagy by inhibiting inositol monophosphatase. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16186256/ · DOI 10.1083/jcb.200504035

    Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19) · lines 88–94

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Monkey COS-7; 10 mM LiCl, LC3 and pathway assays. · source_derived_draft · unverified_draft

    ## lithium-autophagy Cellular recycling can change through a route outside mTOR. Lithium increased autophagy markers through an IMPase-linked route without the mTOR inhibition detected with rapamycin. Model: Monkey COS-7; 10 mM LiCl, LC3 and pathway assays. Limitations: Not evidence that every lithium exposure increases completed autophagic flux or human longevity. Evidence access: Primary full text Lithium induces autophagy by inhibiting inositol monophosphatase. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16186256/ · DOI 10.1083/jcb.200504035
    Complete structured claim and evidence

  2. Lithium treatment increased mono/bis-phosphorylated inositol species in COS-7 cells, consistent with inhibited recycling.

    Lithium ion (Li+) → Inositol monophosphates source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Monkey COS-7 cells; 10 mM LiCl, 24-hour metabolite assay.
    limitations
    Combined IP1–2 measurement; this exposure exceeds typical clinical serum concentrations.
    nutrient_topic
    Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Lithium
    plain_language
    Blocking recycling lets upstream material accumulate.
    primary_references
    Lithium induces autophagy by inhibiting inositol monophosphatase. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16186256/ · DOI 10.1083/jcb.200504035

    Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19) · lines 72–78

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Monkey COS-7 cells; 10 mM LiCl, 24-hour metabolite assay. · source_derived_draft · unverified_draft

    ## lithium-inositol-phosphate-accumulation Blocking recycling lets upstream material accumulate. Lithium treatment increased mono/bis-phosphorylated inositol species in COS-7 cells, consistent with inhibited recycling. Model: Monkey COS-7 cells; 10 mM LiCl, 24-hour metabolite assay. Limitations: Combined IP1–2 measurement; this exposure exceeds typical clinical serum concentrations. Evidence access: Primary full text Lithium induces autophagy by inhibiting inositol monophosphatase. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16186256/ · DOI 10.1083/jcb.200504035
    Complete structured claim and evidence

  3. Lithium lowered IP3 in the COS-7 experiments; added myo-inositol raised it relative to lithium alone.

    Lithium ion (Li+) → IP3 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Monkey COS-7; 10 mM LiCl, 1 mM myo-inositol rescue.
    limitations
    Cell-culture rescue is not a clinical supplement recommendation.
    nutrient_topic
    Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Lithium
    plain_language
    Availability of the precursor changes a signaling messenger.
    primary_references
    Lithium induces autophagy by inhibiting inositol monophosphatase. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16186256/ · DOI 10.1083/jcb.200504035

    Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19) · lines 80–86

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Monkey COS-7; 10 mM LiCl, 1 mM myo-inositol rescue. · source_derived_draft · unverified_draft

    ## lithium-ip3-decrease Availability of the precursor changes a signaling messenger. Lithium lowered IP3 in the COS-7 experiments; added myo-inositol raised it relative to lithium alone. Model: Monkey COS-7; 10 mM LiCl, 1 mM myo-inositol rescue. Limitations: Cell-culture rescue is not a clinical supplement recommendation. Evidence access: Primary full text Lithium induces autophagy by inhibiting inositol monophosphatase. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16186256/ · DOI 10.1083/jcb.200504035
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards