Component
Mitochondrial homeostasis
Independent cellular process record; interpretation is limited by each linked claim and its study context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Excess saccharopine disrupts mitochondrial morphology and function in AASS-domain mutant models.
Experimental context and source evidence
- affected_machinery
- AASS
- availability_state
- machinery_impairment Imported condition classification; unverified.
- deficiency_not_equivalent
- Dietary lysine deficiency
- experimental_model
- Genetic and suppression experiments in worms and mice
- limitations
- Evidence is model-specific, not a toxicity threshold for normal human lysine intake.
- organism
- Caenorhabditis elegans and Mus musculus
- plain_language
- Accumulated saccharopine can harm mitochondria.
- primary_references
- [zhou2019] The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6363459/ DOI: 10.1083/jcb.201807204
- tissue_or_cell_type
- Worm hypodermis and mouse liver
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
L-Lysine: mechanism-first literature curation (2026-09-17) · lines 242–252
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Genetic and suppression experiments in worms and mice · source_derived_draft · unverified_draft
### saccharopine-mitochondrial-toxicity Excess saccharopine disrupts mitochondrial morphology and function in AASS-domain mutant models. Plain language: Accumulated saccharopine can harm mitochondria. Condition category: machinery_impairment organism: Caenorhabditis elegans and Mus musculus tissue_or_cell_type: Worm hypodermis and mouse liver experimental_model: Genetic and suppression experiments in worms and mice limitations: Evidence is model-specific, not a toxicity threshold for normal human lysine intake. affected_machinery: AASS deficiency_not_equivalent: Dietary lysine deficiency [zhou2019] The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6363459/ DOI: 10.1083/jcb.201807204
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.