Component
Mitochondrial calcium uptake
Independent biological entity. Read linked claims for experimental scope and context.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
MCU silencing sharply reduces mitochondrial calcium uptake while membrane potential and respiration remain intact in the tested preparations.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- compartment_description
- Inner mitochondrial membrane
- experimental_model
- Cultured mammalian cells and in vivo mouse-liver MCU silencing
- limitations
- No inference of universal respiratory failure or dietary calcium deficiency.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens and Mus musculus
- plain_language
- Removing MCU prevents rapid calcium uptake without necessarily collapsing the mitochondrion.
- primary_references
- [ca-baughman2011] Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter (2011). https://pubmed.ncbi.nlm.nih.gov/21685886/ DOI: 10.1038/nature10234
- research_relationship_category
- loss_of_function
- tissue_or_cell_type
- Cultured cells and mouse liver
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Calcium: mechanism-first literature curation (2026-09-17) · lines 693–704
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cultured mammalian cells and in vivo mouse-liver MCU silencing · source_derived_draft · unverified_draft
### ca-mcu-loss-matrix-uptake MCU silencing sharply reduces mitochondrial calcium uptake while membrane potential and respiration remain intact in the tested preparations. Condition category: machinery_impairment nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing MCU prevents rapid calcium uptake without necessarily collapsing the mitochondrion. organism: Homo sapiens and Mus musculus tissue_or_cell_type: Cultured cells and mouse liver experimental_model: Cultured mammalian cells and in vivo mouse-liver MCU silencing limitations: No inference of universal respiratory failure or dietary calcium deficiency. research_relationship_category: loss_of_function compartment_description: Inner mitochondrial membrane [ca-baughman2011] Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter (2011). https://pubmed.ncbi.nlm.nih.gov/21685886/ DOI: 10.1038/nature10234
Complete structured claim and evidenceMICU1 limits MCU-dependent calcium uptake at low external calcium in the examined cell preparations.
Experimental context and source evidence
- compartment_description
- Mitochondrial uniporter regulatory machinery
- experimental_model
- HeLa, HEK293 and human endothelial-cell knockdown; calcium-flux and stress assays
- limitations
- Threshold and molecular explanation are assay-dependent; see the separate MICU1 gating conflict.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- MICU1 helps prevent unnecessary calcium accumulation in resting mitochondria.
- primary_references
- [ca-mallilankaraman2012] MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival (2012). https://pubmed.ncbi.nlm.nih.gov/23101630/ DOI: 10.1016/j.cell.2012.10.011
- research_relationship_category
- regulation
- tissue_or_cell_type
- HeLa, HEK293 and endothelial cells
Calcium: mechanism-first literature curation (2026-09-17) · lines 706–717
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · HeLa, HEK293 and human endothelial-cell knockdown; calcium-flux and stress assays · source_derived_draft · unverified_draft
### ca-micu1-basal-uptake-restraint MICU1 limits MCU-dependent calcium uptake at low external calcium in the examined cell preparations. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: MICU1 helps prevent unnecessary calcium accumulation in resting mitochondria. organism: Homo sapiens tissue_or_cell_type: HeLa, HEK293 and endothelial cells experimental_model: HeLa, HEK293 and human endothelial-cell knockdown; calcium-flux and stress assays limitations: Threshold and molecular explanation are assay-dependent; see the separate MICU1 gating conflict. research_relationship_category: regulation compartment_description: Mitochondrial uniporter regulatory machinery [ca-mallilankaraman2012] MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival (2012). https://pubmed.ncbi.nlm.nih.gov/23101630/ DOI: 10.1016/j.cell.2012.10.011
Complete structured claim and evidence
Where it participates (unsigned role)
MCU supplies the inner-mitochondrial-membrane calcium-conducting pore and promotes agonist-evoked matrix calcium uptake.
Experimental context and source evidence
- compartment_description
- Inner mitochondrial membrane
- experimental_model
- Human HeLa MCU silencing/overexpression and purified MCU in planar bilayers
- limitations
- Pore and overexpression evidence; native uptake also depends on accessory subunits and membrane potential.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- MCU lets calcium enter the mitochondrial matrix.
- primary_references
- [ca-destefani2011] A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter (2011). https://pubmed.ncbi.nlm.nih.gov/21685888/ DOI: 10.1038/nature10230
- research_relationship_category
- transport
- tissue_or_cell_type
- HeLa cells and purified channel
- transport_effect
- raises Recorded as promoting agonist-evoked matrix calcium uptake.
- transport_or_reaction_direction
- Intermembrane space to mitochondrial matrix
- transport_pool
- mitochondrial matrix calcium Recorded as promoting agonist-evoked matrix calcium uptake.
Calcium: mechanism-first literature curation (2026-09-17) · lines 679–691
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human HeLa MCU silencing/overexpression and purified MCU in planar bilayers · source_derived_draft · unverified_draft
### ca-mcu-matrix-uptake MCU supplies the inner-mitochondrial-membrane calcium-conducting pore and promotes agonist-evoked matrix calcium uptake. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: MCU lets calcium enter the mitochondrial matrix. organism: Homo sapiens tissue_or_cell_type: HeLa cells and purified channel experimental_model: Human HeLa MCU silencing/overexpression and purified MCU in planar bilayers limitations: Pore and overexpression evidence; native uptake also depends on accessory subunits and membrane potential. research_relationship_category: transport transport_or_reaction_direction: Intermembrane space to mitochondrial matrix compartment_description: Inner mitochondrial membrane [ca-destefani2011] A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter (2011). https://pubmed.ncbi.nlm.nih.gov/21685888/ DOI: 10.1038/nature10230
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.