Component
Carboxylated fraction of circulating MGP
Carboxylated fraction of circulating MGP. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The carboxylated MGP fraction was lower in cases than controls (0.58 versus 0.69), although both absolute MGP forms were higher in cases.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/k2-research/28049648.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e00861b3fa66dc1bd0b5041cd289397c5658586b0656330c6bd77d0097ddd092", "start_char": 0, "end_char": 1485, "text_sha256": "e00861b3fa66dc1bd0b5041cd289397c5658586b0656330c6bd77d0097ddd092"}
- experimental_model
- Matched case-control study
- exposure
- Matching included warfarin use; vitamin K deficiency associations
- limitations
- Observational association; neither causation nor treatment efficacy is established.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- 20 hemodialysis calciphylaxis cases and 20 controls
- plain_language
- Total protein and the fraction correctly modified are different measurements.
- primary_references
- [k2-p28049648] Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis. (2017). https://pubmed.ncbi.nlm.nih.gov/28049648/ DOI: 10.1681/asn.2016060651
- tissue_or_cell_type
- Circulating MGP carboxylation
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1254–1265
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Matched case-control study · source_derived_draft · unverified_draft
### k2-calciphylaxis-marker The carboxylated MGP fraction was lower in cases than controls (0.58 versus 0.69), although both absolute MGP forms were higher in cases. Condition category: biomarker_context nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Total protein and the fraction correctly modified are different measurements. organism: 20 hemodialysis calciphylaxis cases and 20 controls tissue_or_cell_type: Circulating MGP carboxylation experimental_model: Matched case-control study limitations: Observational association; neither causation nor treatment efficacy is established. exposure: Matching included warfarin use; vitamin K deficiency associations evidence_span: {"source_cache": "artifacts/k2-research/28049648.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e00861b3fa66dc1bd0b5041cd289397c5658586b0656330c6bd77d0097ddd092", "start_char": 0, "end_char": 1485, "text_sha256": "e00861b3fa66dc1bd0b5041cd289397c5658586b0656330c6bd77d0097ddd092"} [k2-p28049648] Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis. (2017). https://pubmed.ncbi.nlm.nih.gov/28049648/ DOI: 10.1681/asn.2016060651
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.