{"id":"e1bfef20-4ab2-55a9-bb86-2091a5f397d4","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-calciphylaxis-marker","predicate":"lower_in","statement":"The carboxylated MGP fraction was lower in cases than controls (0.58 versus 0.69), although both absolute MGP forms were higher in cases.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2dcca810-ee04-527b-8aa7-e5b8e24fcdfa","mechanism_event_label":"Total protein and the fraction correctly modified are different measurements.","subject":{"id":"6a42f6af-41ed-5ce5-ab6d-ff9064c566c2","slug":"mgp-carboxylated-fraction","display_name":"Carboxylated fraction of circulating MGP","entity_type_key":"cellular_process"},"object":{"id":"0be89a2a-dbb5-5e88-8b59-e1f2a7140025","slug":"calciphylaxis","display_name":"Calciphylaxis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2dcca810-ee04-527b-8aa7-e5b8e24fcdfa","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-calciphylaxis-marker-event","event_type":"observed_intervention","label":"Total protein and the fraction correctly modified are different measurements.","description":"The carboxylated MGP fraction was lower in cases than controls (0.58 versus 0.69), although both absolute MGP forms were higher in cases.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6a42f6af-41ed-5ce5-ab6d-ff9064c566c2","slug":"mgp-carboxylated-fraction","display_name":"Carboxylated fraction of circulating MGP","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0be89a2a-dbb5-5e88-8b59-e1f2a7140025","slug":"calciphylaxis","display_name":"Calciphylaxis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/k2-research/28049648.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e00861b3fa66dc1bd0b5041cd289397c5658586b0656330c6bd77d0097ddd092\", \"start_char\": 0, \"end_char\": 1485, \"text_sha256\": \"e00861b3fa66dc1bd0b5041cd289397c5658586b0656330c6bd77d0097ddd092\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Matched case-control study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Matching included warfarin use; vitamin K deficiency associations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational association; neither causation nor treatment efficacy is established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"20 hemodialysis calciphylaxis cases and 20 controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Total protein and the fraction correctly modified are different measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k2-p28049648] Vitamin K-Dependent Carboxylation of Matrix Gla Protein Influences the Risk of Calciphylaxis. 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