Component

Human MFSD12 cysteine transport component

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Lysosomes isolated from human HEK293T cells with MFSD12 accumulated more labeled cysteine than lysosomes from MFSD12-knockout cells.

    Human MFSD12 cysteine transport component → Human lysosomal cysteine import source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text; Fig. 4 and transport methods
    experimental_model
    Human HEK293T isolated lysosomes; radiolabeled cysteine transport.
    limitations
    This is lysosomal import; the separate pigment-cell findings connect the same protein to melanosomes. Purified-protein sufficiency was not established.
    nutrient_topic
    L-Tyrosine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Tyrosine
    plain_language
    Pigment-related machinery also handles another amino acid in non-pigmented cells.
    primary_references
    MFSD12 mediates the import of cysteine into melanosomes and lysosomes. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33208952/ · DOI 10.1038/s41586-020-2937-x

    L-Tyrosine: catecholamines, thyroid chemistry, pigment, metabolism and cross-nutrient mechanisms (2026-09-19) · lines 172–178

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human HEK293T isolated lysosomes; radiolabeled cysteine transport. · source_derived_draft · unverified_draft

    ## l-tyrosine-mfsd12-cysteine Pigment-related machinery also handles another amino acid in non-pigmented cells. Lysosomes isolated from human HEK293T cells with MFSD12 accumulated more labeled cysteine than lysosomes from MFSD12-knockout cells. Model: Human HEK293T isolated lysosomes; radiolabeled cysteine transport. Limitations: This is lysosomal import; the separate pigment-cell findings connect the same protein to melanosomes. Purified-protein sufficiency was not established. Evidence access: Primary full text; Fig. 4 and transport methods MFSD12 mediates the import of cysteine into melanosomes and lysosomes. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33208952/ · DOI 10.1038/s41586-020-2937-x
    Complete structured claim and evidence

  2. MFSD12 loss in human SKMEL30 cells reduced melanosomal cystine and cellular cysteinyldopas.

    Human MFSD12 cysteine transport component → Cysteinyldopa isomers, pheomelanin precursors source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text; Fig. 2d–f
    experimental_model
    Human SKMEL30 loss-of-function; analogous mouse experiments were separately reported.
    limitations
    Lysosomal storage and melanosomal pigment endpoints differ.
    nutrient_topic
    L-Tyrosine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Tyrosine
    plain_language
    A missing transporter can redirect pigment chemistry even when precursors exist elsewhere.
    primary_references
    MFSD12 mediates the import of cysteine into melanosomes and lysosomes. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33208952/ · DOI 10.1038/s41586-020-2937-x
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    L-Tyrosine: catecholamines, thyroid chemistry, pigment, metabolism and cross-nutrient mechanisms (2026-09-19) · lines 180–186

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human SKMEL30 loss-of-function; analogous mouse experiments were separately reported. · source_derived_draft · unverified_draft

    ## l-tyrosine-mfsd12-loss A missing transporter can redirect pigment chemistry even when precursors exist elsewhere. MFSD12 loss in human SKMEL30 cells reduced melanosomal cystine and cellular cysteinyldopas. Model: Human SKMEL30 loss-of-function; analogous mouse experiments were separately reported. Limitations: Lysosomal storage and melanosomal pigment endpoints differ. Evidence access: Primary full text; Fig. 2d–f MFSD12 mediates the import of cysteine into melanosomes and lysosomes. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33208952/ · DOI 10.1038/s41586-020-2937-x
    Complete structured claim and evidence

  3. Human HEK293T lysosomes with and without MFSD12 accumulated labeled tyrosine similarly despite the cysteine transport deficit.

    Human MFSD12 cysteine transport component → Human isolated-lysosome tyrosine uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text; Fig. 4d
    experimental_model
    Matched lysosome preparations; 500 nM radiolabeled tyrosine uptake.
    limitations
    This control does not identify the tyrosine transporter.
    nutrient_topic
    L-Tyrosine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Tyrosine
    plain_language
    Sharing an organelle does not mean sharing its transport route.
    primary_references
    MFSD12 mediates the import of cysteine into melanosomes and lysosomes. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33208952/ · DOI 10.1038/s41586-020-2937-x

    L-Tyrosine: catecholamines, thyroid chemistry, pigment, metabolism and cross-nutrient mechanisms (2026-09-19) · lines 188–194

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Matched lysosome preparations; 500 nM radiolabeled tyrosine uptake. · source_derived_draft · unverified_draft

    ## l-tyrosine-mfsd12-tyrosine-control Sharing an organelle does not mean sharing its transport route. Human HEK293T lysosomes with and without MFSD12 accumulated labeled tyrosine similarly despite the cysteine transport deficit. Model: Matched lysosome preparations; 500 nM radiolabeled tyrosine uptake. Limitations: This control does not identify the tyrosine transporter. Evidence access: Primary full text; Fig. 4d MFSD12 mediates the import of cysteine into melanosomes and lysosomes. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33208952/ · DOI 10.1038/s41586-020-2937-x
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards