Component

Methoxsalen / 8-methoxypsoralen

Methoxsalen / 8-methoxypsoralen. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Methoxsalen filled the CYP2A6 active-site cavity without substantially changing the protein structure.

    Methoxsalen / 8-methoxypsoralen → Human cytochrome P450 2A6 / CYP2A6 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coumarin-research/16086027.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "df98434feed879e206e54c520d496e9711581107f6aec58bd9dcc1c74ed5d49d", "start_char": 0, "end_char": 532, "text_sha256": "df98434feed879e206e54c520d496e9711581107f6aec58bd9dcc1c74ed5d49d"}
    experimental_model
    X-ray structures of ligand-bound human CYP2A6
    exposure
    Coumarin and methoxsalen-bound structures
    limitations
    Structure demonstrates binding geometry, not clinical effects or dietary iron responsiveness.
    nutrient_topic
    Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
    organism
    Human protein
    plain_language
    This distinct compound fits into the same enzyme pocket.
    primary_references
    [coumarin-p16086027] Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen. (2005). https://pubmed.ncbi.nlm.nih.gov/16086027/ DOI: 10.1038/nsmb971
    tissue_or_cell_type
    CYP2A6 active site

    Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 176–187

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · X-ray structures of ligand-bound human CYP2A6 · source_derived_draft · unverified_draft

    ### coumarin-methoxsalen-binding Methoxsalen filled the CYP2A6 active-site cavity without substantially changing the protein structure. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: This distinct compound fits into the same enzyme pocket. organism: Human protein tissue_or_cell_type: CYP2A6 active site experimental_model: X-ray structures of ligand-bound human CYP2A6 limitations: Structure demonstrates binding geometry, not clinical effects or dietary iron responsiveness. exposure: Coumarin and methoxsalen-bound structures evidence_span: {"source_cache": "artifacts/coumarin-research/16086027.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "df98434feed879e206e54c520d496e9711581107f6aec58bd9dcc1c74ed5d49d", "start_char": 0, "end_char": 532, "text_sha256": "df98434feed879e206e54c520d496e9711581107f6aec58bd9dcc1c74ed5d49d"} [coumarin-p16086027] Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen. (2005). https://pubmed.ncbi.nlm.nih.gov/16086027/ DOI: 10.1038/nsmb971
    Complete structured claim and evidence

  2. Methoxsalen produced mechanism-based CYP2A6 inhibition, with reported inactivation rate 0.5/min.

    Methoxsalen / 8-methoxypsoralen → Human cytochrome P450 2A6 / CYP2A6 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coumarin-research/9143352.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dca3f4253c2977d47070bb95696634ee2e06fa9a28a3d76ac9790ce695ed6f09", "start_char": 0, "end_char": 2723, "text_sha256": "dca3f4253c2977d47070bb95696634ee2e06fa9a28a3d76ac9790ce695ed6f09"}
    experimental_model
    Human microsomal and recombinant CYP2A6 inhibitor screen
    exposure
    Coumarin 0.5–50 micromolar; 47 inhibitor/substrate probes
    limitations
    In vitro inhibition thresholds are not demonstrated clinical interactions at food exposure.
    nutrient_topic
    Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
    organism
    Human
    plain_language
    Methoxsalen can disable this enzyme during metabolism.
    primary_references
    [coumarin-p9143352] Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. (1997). https://pubmed.ncbi.nlm.nih.gov/9143352/ DOI: 10.1006/abbi.1997.9964
    tissue_or_cell_type
    Liver enzyme preparations

    Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 553–564

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human microsomal and recombinant CYP2A6 inhibitor screen · source_derived_draft · unverified_draft

    ### coumarin-methoxsalen-inactivation Methoxsalen produced mechanism-based CYP2A6 inhibition, with reported inactivation rate 0.5/min. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Methoxsalen can disable this enzyme during metabolism. organism: Human tissue_or_cell_type: Liver enzyme preparations experimental_model: Human microsomal and recombinant CYP2A6 inhibitor screen limitations: In vitro inhibition thresholds are not demonstrated clinical interactions at food exposure. exposure: Coumarin 0.5–50 micromolar; 47 inhibitor/substrate probes evidence_span: {"source_cache": "artifacts/coumarin-research/9143352.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dca3f4253c2977d47070bb95696634ee2e06fa9a28a3d76ac9790ce695ed6f09", "start_char": 0, "end_char": 2723, "text_sha256": "dca3f4253c2977d47070bb95696634ee2e06fa9a28a3d76ac9790ce695ed6f09"} [coumarin-p9143352] Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. (1997). https://pubmed.ncbi.nlm.nih.gov/9143352/ DOI: 10.1006/abbi.1997.9964
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards